CDX-2 expression correlates with clinical outcomes in MSI-H metastatic colorectal cancer patients receiving immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) showed efficacy in metastatic colorectal cancer (mCRC) with mismatch-repair deficiency or high microsatellite instability (dMMR-MSI-H). Unfortunately, a patient’s subgroup did not benefit from immunotherapy. Caudal-related homeobox transcription factor 2 (CDX-2) w...

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Detalles Bibliográficos
Autores principales: Ziranu, Pina, Pretta, Andrea, Pozzari, Marta, Maccioni, Antonio, Badiali, Manuela, Fanni, Daniela, Lai, Eleonora, Donisi, Clelia, Persano, Mara, Gerosa, Clara, Puzzoni, Marco, Bardanzellu, Fabio, Ambu, Rossano, Pusceddu, Valeria, Dubois, Marco, Cerrone, Giulia, Migliari, Marco, Murgia, Sara, Spanu, Dario, Pretta, Gianluca, Aimola, Valentina, Balconi, Francesca, Murru, Stefania, Faa, Gavino, Scartozzi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020482/
https://www.ncbi.nlm.nih.gov/pubmed/36928082
http://dx.doi.org/10.1038/s41598-023-31538-3

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