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The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth
Externalizing behaviors in childhood often predict impulse control disorders in adulthood; however, the underlying bio-behavioral risk factors are incompletely understood. In animals, the propensity to sign-track, or the degree to which incentive motivational value is attributed to reward cues, is a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020483/ https://www.ncbi.nlm.nih.gov/pubmed/36928057 http://dx.doi.org/10.1038/s41598-023-30906-3 |
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author | Colaizzi, Janna M. Flagel, Shelly B. Gearhardt, Ashley N. Borowitz, Michelle A. Kuplicki, Rayus Zotev, Vadim Clark, Grace Coronado, Jennifer Abbott, Talia Paulus, Martin P. |
author_facet | Colaizzi, Janna M. Flagel, Shelly B. Gearhardt, Ashley N. Borowitz, Michelle A. Kuplicki, Rayus Zotev, Vadim Clark, Grace Coronado, Jennifer Abbott, Talia Paulus, Martin P. |
author_sort | Colaizzi, Janna M. |
collection | PubMed |
description | Externalizing behaviors in childhood often predict impulse control disorders in adulthood; however, the underlying bio-behavioral risk factors are incompletely understood. In animals, the propensity to sign-track, or the degree to which incentive motivational value is attributed to reward cues, is associated with externalizing-type behaviors and deficits in executive control. Using a Pavlovian conditioned approach paradigm, we quantified sign-tracking in 40 healthy 9–12-year-olds. We also measured parent-reported externalizing behaviors and anticipatory neural activations to outcome-predicting cues using the monetary incentive delay fMRI task. Sign-tracking was associated with attentional and inhibitory control deficits and the degree of amygdala, but not cortical, activation during reward anticipation. These findings support the hypothesis that youth with a propensity to sign-track are prone to externalizing tendencies, with an over-reliance on subcortical cue-reactive brain systems. This research highlights sign-tracking as a promising experimental approach delineating the behavioral and neural circuitry of individuals at risk for externalizing disorders. |
format | Online Article Text |
id | pubmed-10020483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100204832023-03-18 The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth Colaizzi, Janna M. Flagel, Shelly B. Gearhardt, Ashley N. Borowitz, Michelle A. Kuplicki, Rayus Zotev, Vadim Clark, Grace Coronado, Jennifer Abbott, Talia Paulus, Martin P. Sci Rep Article Externalizing behaviors in childhood often predict impulse control disorders in adulthood; however, the underlying bio-behavioral risk factors are incompletely understood. In animals, the propensity to sign-track, or the degree to which incentive motivational value is attributed to reward cues, is associated with externalizing-type behaviors and deficits in executive control. Using a Pavlovian conditioned approach paradigm, we quantified sign-tracking in 40 healthy 9–12-year-olds. We also measured parent-reported externalizing behaviors and anticipatory neural activations to outcome-predicting cues using the monetary incentive delay fMRI task. Sign-tracking was associated with attentional and inhibitory control deficits and the degree of amygdala, but not cortical, activation during reward anticipation. These findings support the hypothesis that youth with a propensity to sign-track are prone to externalizing tendencies, with an over-reliance on subcortical cue-reactive brain systems. This research highlights sign-tracking as a promising experimental approach delineating the behavioral and neural circuitry of individuals at risk for externalizing disorders. Nature Publishing Group UK 2023-03-16 /pmc/articles/PMC10020483/ /pubmed/36928057 http://dx.doi.org/10.1038/s41598-023-30906-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Colaizzi, Janna M. Flagel, Shelly B. Gearhardt, Ashley N. Borowitz, Michelle A. Kuplicki, Rayus Zotev, Vadim Clark, Grace Coronado, Jennifer Abbott, Talia Paulus, Martin P. The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
title | The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
title_full | The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
title_fullStr | The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
title_full_unstemmed | The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
title_short | The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
title_sort | propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020483/ https://www.ncbi.nlm.nih.gov/pubmed/36928057 http://dx.doi.org/10.1038/s41598-023-30906-3 |
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