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Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water

Physical and chemical changes in the natural of water may affect biological organisms. In this study, we highlight the effect of magnetized-water and microwave-water on rats’ liver tissues. Three groups of albino rats were separated. The first, rats were administered tap-water. The second, rats were...

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Autores principales: Elmoslemany, Amira M., Ghamry, Heba I., Awad, Abdelrahman A., EL-Kholy, Ragab I., Almami, Ibtesam S. M., Alyamani, Najiah M., Zedan, Amina M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020533/
https://www.ncbi.nlm.nih.gov/pubmed/36928800
http://dx.doi.org/10.1038/s41598-023-31168-9
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author Elmoslemany, Amira M.
Ghamry, Heba I.
Awad, Abdelrahman A.
EL-Kholy, Ragab I.
Almami, Ibtesam S. M.
Alyamani, Najiah M.
Zedan, Amina M. G.
author_facet Elmoslemany, Amira M.
Ghamry, Heba I.
Awad, Abdelrahman A.
EL-Kholy, Ragab I.
Almami, Ibtesam S. M.
Alyamani, Najiah M.
Zedan, Amina M. G.
author_sort Elmoslemany, Amira M.
collection PubMed
description Physical and chemical changes in the natural of water may affect biological organisms. In this study, we highlight the effect of magnetized-water and microwave-water on rats’ liver tissues. Three groups of albino rats were separated. The first, rats were administered tap-water. The second, rats were administered magnetized-water. The third, rats were administered microwave-water. After two months, the results revealed a significant increase in liver functioning enzymes’ levels and bilirubin in rats administered microwave-water, compared to tap- and magnetic-water. In relation to oxidative stress, there was a significant increase and decrease in oxidative and antioxidant parameters respectively in liver tissues of rat's administrated microwave-water. At the molecular level, there was a significant down-regulation in Metallothionein, CYP genes in magnetic-water compared to tap-water. Rats administered microwave-water have shown a significant down-regulation in GST, Metallothionein and CYP genes’ expression, however, Amylase and HDAC3 genes were significantly up-regulated, compared to the other groups. The intake of microwave-water resulted in notable histopathological changes in liver tissues. Rats administered magnetic-water showed no clear changes in their liver tissues. In summary, microwave-water induced stress and epigenetic effects compared with magnetic-water and tap-water. Also, magnetic-water produced from the higher magnetic power had no side effect on liver tissues.
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spelling pubmed-100205332023-03-18 Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water Elmoslemany, Amira M. Ghamry, Heba I. Awad, Abdelrahman A. EL-Kholy, Ragab I. Almami, Ibtesam S. M. Alyamani, Najiah M. Zedan, Amina M. G. Sci Rep Article Physical and chemical changes in the natural of water may affect biological organisms. In this study, we highlight the effect of magnetized-water and microwave-water on rats’ liver tissues. Three groups of albino rats were separated. The first, rats were administered tap-water. The second, rats were administered magnetized-water. The third, rats were administered microwave-water. After two months, the results revealed a significant increase in liver functioning enzymes’ levels and bilirubin in rats administered microwave-water, compared to tap- and magnetic-water. In relation to oxidative stress, there was a significant increase and decrease in oxidative and antioxidant parameters respectively in liver tissues of rat's administrated microwave-water. At the molecular level, there was a significant down-regulation in Metallothionein, CYP genes in magnetic-water compared to tap-water. Rats administered microwave-water have shown a significant down-regulation in GST, Metallothionein and CYP genes’ expression, however, Amylase and HDAC3 genes were significantly up-regulated, compared to the other groups. The intake of microwave-water resulted in notable histopathological changes in liver tissues. Rats administered magnetic-water showed no clear changes in their liver tissues. In summary, microwave-water induced stress and epigenetic effects compared with magnetic-water and tap-water. Also, magnetic-water produced from the higher magnetic power had no side effect on liver tissues. Nature Publishing Group UK 2023-03-16 /pmc/articles/PMC10020533/ /pubmed/36928800 http://dx.doi.org/10.1038/s41598-023-31168-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Elmoslemany, Amira M.
Ghamry, Heba I.
Awad, Abdelrahman A.
EL-Kholy, Ragab I.
Almami, Ibtesam S. M.
Alyamani, Najiah M.
Zedan, Amina M. G.
Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
title Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
title_full Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
title_fullStr Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
title_full_unstemmed Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
title_short Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
title_sort liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020533/
https://www.ncbi.nlm.nih.gov/pubmed/36928800
http://dx.doi.org/10.1038/s41598-023-31168-9
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