Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1

DNA ligase I (LigI), the predominant enzyme that joins Okazaki fragments, interacts with PCNA and Pol δ. LigI also interacts with UHRF1, linking Okazaki fragment joining with DNA maintenance methylation. Okazaki fragments can also be joined by a relatively poorly characterized DNA ligase IIIα (LigII...

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Detalles Bibliográficos
Autores principales: Bhandari, Seema Khattri, Wiest, Nathaniel, Sallmyr, Annahita, Du, Ruofei, Ferry, Laure, Defossez, Pierre-Antoine, Tomkinson, Alan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020546/
https://www.ncbi.nlm.nih.gov/pubmed/36928068
http://dx.doi.org/10.1038/s41598-023-31367-4

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