B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

Protection from viral infections depends on immunoglobulin isotype switching, which endows antibodies with effector functions. Here, we find that the protein kinase DYRK1A is essential for B cell-mediated protection from viral infection and effective vaccination through regulation of class switch re...

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Detalles Bibliográficos
Autores principales: Stoler-Barak, Liat, Harris, Ethan, Peres, Ayelet, Hezroni, Hadas, Kuka, Mirela, Di Lucia, Pietro, Grenov, Amalie, Gurwicz, Neta, Kupervaser, Meital, Yip, Bon Ham, Iannacone, Matteo, Yaari, Gur, Crispino, John D., Shulman, Ziv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020581/
https://www.ncbi.nlm.nih.gov/pubmed/36927854
http://dx.doi.org/10.1038/s41467-023-37205-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020581/
https://www.ncbi.nlm.nih.gov/pubmed/36927854
http://dx.doi.org/10.1038/s41467-023-37205-5

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