Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer

The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca(2+) phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and di...

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Detalles Bibliográficos
Autores principales: Zhang, Huhu, Zhang, Zhe, Guo, Tingting, Chen, Guang, Liu, Guoxiang, Song, Qinghang, Li, Guichun, Xu, Fenghua, Dong, Xiaolei, Yang, Fanghao, Cao, Can, Zhong, Di, Li, Shuang, Li, Ya, Wang, Mengjun, Li, Bing, Yang, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020606/
https://www.ncbi.nlm.nih.gov/pubmed/36936694
http://dx.doi.org/10.3389/fcell.2023.1141331
Descripción
Sumario:The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca(2+) phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer.

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