Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer

The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca(2+) phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and di...

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Autores principales: Zhang, Huhu, Zhang, Zhe, Guo, Tingting, Chen, Guang, Liu, Guoxiang, Song, Qinghang, Li, Guichun, Xu, Fenghua, Dong, Xiaolei, Yang, Fanghao, Cao, Can, Zhong, Di, Li, Shuang, Li, Ya, Wang, Mengjun, Li, Bing, Yang, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020606/
https://www.ncbi.nlm.nih.gov/pubmed/36936694
http://dx.doi.org/10.3389/fcell.2023.1141331
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author Zhang, Huhu
Zhang, Zhe
Guo, Tingting
Chen, Guang
Liu, Guoxiang
Song, Qinghang
Li, Guichun
Xu, Fenghua
Dong, Xiaolei
Yang, Fanghao
Cao, Can
Zhong, Di
Li, Shuang
Li, Ya
Wang, Mengjun
Li, Bing
Yang, Lina
author_facet Zhang, Huhu
Zhang, Zhe
Guo, Tingting
Chen, Guang
Liu, Guoxiang
Song, Qinghang
Li, Guichun
Xu, Fenghua
Dong, Xiaolei
Yang, Fanghao
Cao, Can
Zhong, Di
Li, Shuang
Li, Ya
Wang, Mengjun
Li, Bing
Yang, Lina
author_sort Zhang, Huhu
collection PubMed
description The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca(2+) phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer.
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spelling pubmed-100206062023-03-18 Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer Zhang, Huhu Zhang, Zhe Guo, Tingting Chen, Guang Liu, Guoxiang Song, Qinghang Li, Guichun Xu, Fenghua Dong, Xiaolei Yang, Fanghao Cao, Can Zhong, Di Li, Shuang Li, Ya Wang, Mengjun Li, Bing Yang, Lina Front Cell Dev Biol Cell and Developmental Biology The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca(2+) phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer. Frontiers Media S.A. 2023-03-03 /pmc/articles/PMC10020606/ /pubmed/36936694 http://dx.doi.org/10.3389/fcell.2023.1141331 Text en Copyright © 2023 Zhang, Zhang, Guo, Chen, Liu, Song, Li, Xu, Dong, Yang, Cao, Zhong, Li, Li, Wang, Li and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhang, Huhu
Zhang, Zhe
Guo, Tingting
Chen, Guang
Liu, Guoxiang
Song, Qinghang
Li, Guichun
Xu, Fenghua
Dong, Xiaolei
Yang, Fanghao
Cao, Can
Zhong, Di
Li, Shuang
Li, Ya
Wang, Mengjun
Li, Bing
Yang, Lina
Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
title Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
title_full Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
title_fullStr Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
title_full_unstemmed Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
title_short Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
title_sort annexin a protein family: focusing on the occurrence, progression and treatment of cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020606/
https://www.ncbi.nlm.nih.gov/pubmed/36936694
http://dx.doi.org/10.3389/fcell.2023.1141331
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