Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase

Plasma thymidine levels in rodents are higher than in other mammals including humans, possibly due to a different pattern and lower level of thymidine phosphorylase expression. Here, we generated a novel knock-in (KI) mouse line with high systemic expression of human thymidine phosphorylase to inves...

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Detalles Bibliográficos
Autores principales: Harada, Naomoto, Nagasaki, Haruka, Yamamoto, Hiromi, Matsubara, Kenji, Suzuki, Takamasa, Gomori, Akira, Yokogawa, Tatsushi, Matsuo, Kenichi, Miyadera, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020661/
https://www.ncbi.nlm.nih.gov/pubmed/36773803
http://dx.doi.org/10.1016/j.jbc.2023.103002

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