Cargando…

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice

The polarization of microglia plays an important role in the outcome of ischemic stroke (IS). In the aged population, senescent microglia show a predominant pro-inflammatory phenotype, which leads to worse outcomes in aged ischemic stroke compared to young ischemic stroke. Recent research demonstrat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niu, Xinyu, Xia, Yuguo, Luo, Lei, Chen, Yu, Yuan, Ji, Zhang, Juntao, Zheng, Xianyou, Li, Qing, Deng, Zhifeng, Wang, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020681/ https://www.ncbi.nlm.nih.gov/pubmed/36936398 http://dx.doi.org/10.1016/j.mtbio.2023.100600

Ejemplares similares

ESC‐sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia
por: Hu, Guowen, et al.
Publicado: (2020)

Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells
por: Gong, Liangzhi, et al.
Publicado: (2020)

MiR-106b-5p Regulates the Reprogramming of Spermatogonial Stem Cells into iPSC (Induced Pluripotent Stem Cell)-Like Cells
por: Hasani Fard, Amir Hossein, et al.
Publicado: (2022)

Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke
por: Xia, Yuguo, et al.
Publicado: (2020)

Detection of Inflammation-Related Melanoma Small Extracellular Vesicle (sEV) mRNA Content Using Primary Melanocyte sEVs as a Reference
por: Bardi, Gina T., et al.
Publicado: (2019)

Signaling of Tumor-Derived sEV Impacts Melanoma Progression
por: Zebrowska, Aneta, et al.
Publicado: (2020)

Generation of iPSC-based human-mouse microglial brain chimeras to study senescence of human microglia
por: Jin, Mengmeng, et al.
Publicado: (2022)

Neutrophil membrane engineered HucMSC sEVs alleviate cisplatin-induced AKI by enhancing cellular uptake and targeting
por: Wu, Peipei, et al.
Publicado: (2022)

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells
por: Hinger, Scott A., et al.
Publicado: (2020)

Effects of sEV derived from SHED and DPSC on the proliferation, migration and osteogenesis of PDLSC
por: Zheng, Yexin, et al.
Publicado: (2023)

Regenerative and protective effects of dMSC-sEVs on high-glucose-induced senescent fibroblasts by suppressing RAGE pathway and activating Smad pathway
por: Bian, Xiaowei, et al.
Publicado: (2020)

Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk
por: Lv, Jianlu, et al.
Publicado: (2022)

Proof of concept of using a membrane-sensing peptide for sEVs affinity-based isolation
por: Benayas, Beatriz, et al.
Publicado: (2023)

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
por: Abreu, Celina Monteiro, et al.
Publicado: (2018)

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models
por: Hedegaard, Anne, et al.
Publicado: (2020)

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022)

Increased extracellular vesicles (EVs) related to T cell-mediated inflammation and vascular function in familial hypercholesterolemia
por: Nielsen, Morten Hjuler, et al.
Publicado: (2023)

Activation of Toll-Like Receptors 2 by High-Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke
por: Sadat-Hatamnezhad, Leila, et al.
Publicado: (2016)

FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis
por: He, Siyuan, et al.
Publicado: (2022)

iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease
por: Badanjak, Katja, et al.
Publicado: (2021)

Cell‐Based Therapy for Canavan Disease Using Human iPSC‐Derived NPCs and OPCs
por: Feng, Lizhao, et al.
Publicado: (2020)

A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission
por: Lafourcade, Carlos Andrés, et al.
Publicado: (2020)

Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)
por: Tan, Thong Teck, et al.
Publicado: (2021)

Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood
por: Matsumoto, Akihiro, et al.
Publicado: (2021)

Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage
por: Dou, Yunxiao, et al.
Publicado: (2021)

Small Extracellular Vesicles (sEVs) Biogenesis Molecular Players Are Associated with Clinical Outcome of Colorectal Cancer Patients
por: Kottorou, Anastasia, et al.
Publicado: (2023)

Microglia in the human infant brain and factors that affect expression
por: Ambrose, Natalie, et al.
Publicado: (2020)

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells
por: Bhat, Anjali, et al.
Publicado: (2022)

Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells
por: Fernandez-Rebollo, Eduardo, et al.
Publicado: (2020)

Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy
por: Tang, Rongbing, et al.
Publicado: (2023)

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
por: Bassil, Reina, et al.
Publicado: (2021)

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
por: Vahsen, Björn F., et al.
Publicado: (2022)

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia
por: Stöberl, Nina, et al.
Publicado: (2023)

sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p
por: Kim, Jieun, et al.
Publicado: (2021)

Ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses()
por: Sanchez, Kevin, et al.
Publicado: (2023)

Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells
por: Zavala, Gabriela, et al.
Publicado: (2020)

αvβ3-targeted sEVs for efficient intracellular delivery of proteins using MFG-E8
por: Mai, Junxin, et al.
Publicado: (2022)

SERS spectroscopy with machine learning to analyze human plasma derived sEVs for coronary artery disease diagnosis and prognosis
por: Huang, Xi, et al.
Publicado: (2022)

Hypoxic culture of umbilical cord mesenchymal stem cell-derived sEVs prompts peripheral nerve injury repair
por: Zhu, Ziying, et al.
Publicado: (2023)

MSC−sEV Treatment Polarizes Pro−Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH
por: Zhang, Bin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_p02trtrf1vbn0cb0dp8m3jl2tk