Evidence Regarding Pharmacogenetics in Pain Management and Cancer

Patients experience interindividual variation in response to analgesics, which may be partially explained by genetics. This commentary discusses a recently published trial on COMT genotype and opioid dose requirements and describes the potential role for COMT and other genes (eg, CYP2D6) on opioid t...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, D Max, Figg, William D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020807/
https://www.ncbi.nlm.nih.gov/pubmed/36718020
http://dx.doi.org/10.1093/oncolo/oyac277
Descripción
Sumario:Patients experience interindividual variation in response to analgesics, which may be partially explained by genetics. This commentary discusses a recently published trial on COMT genotype and opioid dose requirements and describes the potential role for COMT and other genes (eg, CYP2D6) on opioid therapy and the current evidence for germline pharmacogenetics and resources for opioid pharmacogenetics.

Ejemplares similares