Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors

BACKGROUND: Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of transforming growth factor beta receptor II (a TGF-β “trap”) fused to a human immunoglobulin G1 monoclonal antibody blocking programmed cell death 1 ligand 1 (PD-L1). We report the eff...

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Detalles Bibliográficos
Autores principales: Barlesi, Fabrice, Isambert, Nicolas, Felip, Enriqueta, Cho, Byoung Chul, Lee, Dae Ho, Peguero, Julio, Jerusalem, Guy, Penel, Nicolas, Saada-Bouzid, Esma, Garrido, Pilar, Helwig, Christoph, Locke, George, Ojalvo, Laureen S, Gulley, James L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Lung Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020814/
https://www.ncbi.nlm.nih.gov/pubmed/36571770
http://dx.doi.org/10.1093/oncolo/oyac253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020814/
https://www.ncbi.nlm.nih.gov/pubmed/36571770
http://dx.doi.org/10.1093/oncolo/oyac253

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