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Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization

[Image: see text] The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric modulator of a full-length α7nAChR and an agonist of the α7nAChR construct containing transmembrane (TM...

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Detalles Bibliográficos
Autores principales:	Bondarenko, Vasyl, Chen, Qiang, Singewald, Kevin, Haloi, Nandan, Tillman, Tommy S., Howard, Rebecca J., Lindahl, Erik, Xu, Yan, Tang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020961/ https://www.ncbi.nlm.nih.gov/pubmed/36821490 http://dx.doi.org/10.1021/acschemneuro.2c00783

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