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Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology

[Image: see text] GlycoConnect technology can be readily adapted to provide different drug-to-antibody ratios (DARs) and is currently also evaluated in various clinical programs, including ADCT-601 (DAR2), MRG004a (DAR4), and XMT-1660 (DAR6). While antibody-drug conjugates (ADCs) typically feature a...

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Detalles Bibliográficos
Autores principales:	de Bever, Laureen, Popal, Sorraya, van Schaik, Jord, Rubahamya, Baron, van Delft, Floris L., Thurber, Greg M., van Berkel, Sander S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020967/ https://www.ncbi.nlm.nih.gov/pubmed/36857521 http://dx.doi.org/10.1021/acs.bioconjchem.2c00611

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