Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis. Intra-articular gene delivery to block proinflammatory cytokines has been studied in pre-clinical models and human clinical trials. It has been demonstrated that the level of programmed death-ligand 1...

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Detalles Bibliográficos
Autores principales: Li, Wenjun, Sun, Junjiang, Feng, Susi Liu, Wang, Feng, Miao, Michael Z., Wu, Eveline Y., Wallet, Shannon, Loeser, Richard, Li, Chengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021025/
https://www.ncbi.nlm.nih.gov/pubmed/36936967
http://dx.doi.org/10.3389/fimmu.2023.1116084

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