Cargando…

KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report

Metaplastic Breast Cancer (MBC) is a rare group of tumors often presenting as triple-negative. MBC accounts for less than 1% of all breast cancers with the spindle cell variant comprising less than 0.5%. While rare, spindle cell carcinoma is the commonest subtype in the western world. It has a more...

Descripción completa

Detalles Bibliográficos
Autores principales: Niver, Harper E, Foxhall, Edward, Lahiry, Anup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021088/
https://www.ncbi.nlm.nih.gov/pubmed/36937820
http://dx.doi.org/10.1177/20363613231163730
_version_ 1784908397638844416
author Niver, Harper E
Foxhall, Edward
Lahiry, Anup
author_facet Niver, Harper E
Foxhall, Edward
Lahiry, Anup
author_sort Niver, Harper E
collection PubMed
description Metaplastic Breast Cancer (MBC) is a rare group of tumors often presenting as triple-negative. MBC accounts for less than 1% of all breast cancers with the spindle cell variant comprising less than 0.5%. While rare, spindle cell carcinoma is the commonest subtype in the western world. It has a more aggressive biological behavior with increased risk of recurrence and death due to disease compared to triple negative breast cancers. There is no treatment guideline for management of MBC due to the rarity of the disease. Instead, treatment is theorized based off success with other types of aggressive breast and metaplastic cancers of different tissue. We present the first known case report of male spindle cell carcinoma of the breast treated with KEYNOTE-522 regimen. Therapy included a first phase with pembrolizumab (dose of 200 mg) every 3 weeks plus paclitaxel and carboplatin and second phase, with four cycles of pembrolizumab with doxorubicin-cyclophosphamide.
format Online
Article
Text
id pubmed-10021088
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-100210882023-03-18 KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report Niver, Harper E Foxhall, Edward Lahiry, Anup Rare Tumors Case Report Metaplastic Breast Cancer (MBC) is a rare group of tumors often presenting as triple-negative. MBC accounts for less than 1% of all breast cancers with the spindle cell variant comprising less than 0.5%. While rare, spindle cell carcinoma is the commonest subtype in the western world. It has a more aggressive biological behavior with increased risk of recurrence and death due to disease compared to triple negative breast cancers. There is no treatment guideline for management of MBC due to the rarity of the disease. Instead, treatment is theorized based off success with other types of aggressive breast and metaplastic cancers of different tissue. We present the first known case report of male spindle cell carcinoma of the breast treated with KEYNOTE-522 regimen. Therapy included a first phase with pembrolizumab (dose of 200 mg) every 3 weeks plus paclitaxel and carboplatin and second phase, with four cycles of pembrolizumab with doxorubicin-cyclophosphamide. SAGE Publications 2023-03-15 /pmc/articles/PMC10021088/ /pubmed/36937820 http://dx.doi.org/10.1177/20363613231163730 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Niver, Harper E
Foxhall, Edward
Lahiry, Anup
KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report
title KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report
title_full KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report
title_fullStr KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report
title_full_unstemmed KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report
title_short KEYNOTE—522 and male spindle cell carcinoma of the breast: A case report
title_sort keynote—522 and male spindle cell carcinoma of the breast: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021088/
https://www.ncbi.nlm.nih.gov/pubmed/36937820
http://dx.doi.org/10.1177/20363613231163730
work_keys_str_mv AT niverharpere keynote522andmalespindlecellcarcinomaofthebreastacasereport
AT foxhalledward keynote522andmalespindlecellcarcinomaofthebreastacasereport
AT lahiryanup keynote522andmalespindlecellcarcinomaofthebreastacasereport