Cargando…

Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study

Tuberculosis (TB) remains a major medical and public health problem throughout the world, especially in developing countries including Ethiopia. Its control program is currently being challenged by the spread of drug-resistant TB, which is the result of poor treatment outcomes. Hence, this study ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Mengesha, Melkamu Merid, Gebremichael, Mathewos Alemu, Watumo, Desta, Hallström, Inger Kristensson, Jerene, Degu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021194/
https://www.ncbi.nlm.nih.gov/pubmed/36962264
http://dx.doi.org/10.1371/journal.pgph.0000161
_version_ 1784908424361803776
author Mengesha, Melkamu Merid
Gebremichael, Mathewos Alemu
Watumo, Desta
Hallström, Inger Kristensson
Jerene, Degu
author_facet Mengesha, Melkamu Merid
Gebremichael, Mathewos Alemu
Watumo, Desta
Hallström, Inger Kristensson
Jerene, Degu
author_sort Mengesha, Melkamu Merid
collection PubMed
description Tuberculosis (TB) remains a major medical and public health problem throughout the world, especially in developing countries including Ethiopia. Its control program is currently being challenged by the spread of drug-resistant TB, which is the result of poor treatment outcomes. Hence, this study assessed poor adult TB treatment outcomes and associated factors in Gibe Woreda, Southern Ethiopia. An institution-based cross-sectional study was conducted from March 1, 2020 to March 30, 2020, using a standard checklist to review clinical charts of TB patients who enrolled on first-line TB treatment under DOTS between June 2016 and June 2019. Poor treatment outcomes constituted death during treatment, treatment failure, and loss to follow-up (LTFU). Descriptive statistics were used to describe the characteristics of study participants. A binary logistic regression model was fitted to identify factors influencing treatment outcome and adjusted odds ratios with a 95% confidence interval were reported. The statistical significance of all tests in this study was declared at P-value <5%. A total of 400 adult TB patients were participated. The mean age of study participants was 39.2±16.7 years, 55.5% were males and 79.8% were pulmonary tuberculosis cases. Regarding the treatment outcomes, 58% completed treatment, 27.5% cured, 9.3% were LTFU, 3.2% died, and 2.0% failed. The overall poor treatment outcome was 14.5% (95% CI: 11.1–17.9). Age (aOR = 1.02; 95%CI: 1.01–1.04), male gender (aOR = 1.82; 95% CI: 0.99–3.73), travel ≥ 10 kilometres to receive TB treatment (aOR = 6.55; 95% CI: 3.02–14.19), and lack of family support during the course of treatment (aOR = 3.03; 95% CI: 1.37–6.70), and bedridden baseline functional status (aOR = 4.40; 95% CI: 0.96–20.06) were factors associated with poor treatment outcome. Successful TB treatment outcome in this study area was below the national TB treatment success rate. To improve positive treatment outcomes, remote areas should be prioritized for TB interventions, and stakeholders in TB treatment and care should give special emphasis to adults over the age of 45 years, males, those who travel more than 10 kilometres to receive TB care, having bedridden baseline functional status and those who had no family support.
format Online
Article
Text
id pubmed-10021194
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-100211942023-03-17 Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study Mengesha, Melkamu Merid Gebremichael, Mathewos Alemu Watumo, Desta Hallström, Inger Kristensson Jerene, Degu PLOS Glob Public Health Research Article Tuberculosis (TB) remains a major medical and public health problem throughout the world, especially in developing countries including Ethiopia. Its control program is currently being challenged by the spread of drug-resistant TB, which is the result of poor treatment outcomes. Hence, this study assessed poor adult TB treatment outcomes and associated factors in Gibe Woreda, Southern Ethiopia. An institution-based cross-sectional study was conducted from March 1, 2020 to March 30, 2020, using a standard checklist to review clinical charts of TB patients who enrolled on first-line TB treatment under DOTS between June 2016 and June 2019. Poor treatment outcomes constituted death during treatment, treatment failure, and loss to follow-up (LTFU). Descriptive statistics were used to describe the characteristics of study participants. A binary logistic regression model was fitted to identify factors influencing treatment outcome and adjusted odds ratios with a 95% confidence interval were reported. The statistical significance of all tests in this study was declared at P-value <5%. A total of 400 adult TB patients were participated. The mean age of study participants was 39.2±16.7 years, 55.5% were males and 79.8% were pulmonary tuberculosis cases. Regarding the treatment outcomes, 58% completed treatment, 27.5% cured, 9.3% were LTFU, 3.2% died, and 2.0% failed. The overall poor treatment outcome was 14.5% (95% CI: 11.1–17.9). Age (aOR = 1.02; 95%CI: 1.01–1.04), male gender (aOR = 1.82; 95% CI: 0.99–3.73), travel ≥ 10 kilometres to receive TB treatment (aOR = 6.55; 95% CI: 3.02–14.19), and lack of family support during the course of treatment (aOR = 3.03; 95% CI: 1.37–6.70), and bedridden baseline functional status (aOR = 4.40; 95% CI: 0.96–20.06) were factors associated with poor treatment outcome. Successful TB treatment outcome in this study area was below the national TB treatment success rate. To improve positive treatment outcomes, remote areas should be prioritized for TB interventions, and stakeholders in TB treatment and care should give special emphasis to adults over the age of 45 years, males, those who travel more than 10 kilometres to receive TB care, having bedridden baseline functional status and those who had no family support. Public Library of Science 2022-03-10 /pmc/articles/PMC10021194/ /pubmed/36962264 http://dx.doi.org/10.1371/journal.pgph.0000161 Text en © 2022 Mengesha et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mengesha, Melkamu Merid
Gebremichael, Mathewos Alemu
Watumo, Desta
Hallström, Inger Kristensson
Jerene, Degu
Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study
title Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study
title_full Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study
title_fullStr Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study
title_full_unstemmed Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study
title_short Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study
title_sort poor adult tuberculosis treatment outcome and associated factors in gibe woreda, southern ethiopia: an institution-based cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021194/
https://www.ncbi.nlm.nih.gov/pubmed/36962264
http://dx.doi.org/10.1371/journal.pgph.0000161
work_keys_str_mv AT mengeshamelkamumerid pooradulttuberculosistreatmentoutcomeandassociatedfactorsingibeworedasouthernethiopiaaninstitutionbasedcrosssectionalstudy
AT gebremichaelmathewosalemu pooradulttuberculosistreatmentoutcomeandassociatedfactorsingibeworedasouthernethiopiaaninstitutionbasedcrosssectionalstudy
AT watumodesta pooradulttuberculosistreatmentoutcomeandassociatedfactorsingibeworedasouthernethiopiaaninstitutionbasedcrosssectionalstudy
AT hallstromingerkristensson pooradulttuberculosistreatmentoutcomeandassociatedfactorsingibeworedasouthernethiopiaaninstitutionbasedcrosssectionalstudy
AT jerenedegu pooradulttuberculosistreatmentoutcomeandassociatedfactorsingibeworedasouthernethiopiaaninstitutionbasedcrosssectionalstudy