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Critical weaknesses in shielding strategies for COVID-19

The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to a wide range of non-pharmaceutical interventions being implemented around the world to curb transmission. However, the economic and social costs of some of these measures, especially lockdowns, has been high. An alternative and...

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Detalles Bibliográficos
Autores principales: Smith, Cameron A., Yates, Christian A., Ashby, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021285/
https://www.ncbi.nlm.nih.gov/pubmed/36962415
http://dx.doi.org/10.1371/journal.pgph.0000298
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author Smith, Cameron A.
Yates, Christian A.
Ashby, Ben
author_facet Smith, Cameron A.
Yates, Christian A.
Ashby, Ben
author_sort Smith, Cameron A.
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description The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to a wide range of non-pharmaceutical interventions being implemented around the world to curb transmission. However, the economic and social costs of some of these measures, especially lockdowns, has been high. An alternative and widely discussed public health strategy for the COVID-19 pandemic would have been to ‘shield’ those most vulnerable to COVID-19 (minimising their contacts with others), while allowing infection to spread among lower risk individuals with the aim of reaching herd immunity. Here we retrospectively explore the effectiveness of this strategy using a stochastic SEIR framework, showing that even under the unrealistic assumption of perfect shielding, hospitals would have been rapidly overwhelmed with many avoidable deaths among lower risk individuals. Crucially, even a small (20%) reduction in the effectiveness of shielding would have likely led to a large increase (>150%) in the number of deaths compared to perfect shielding. Our findings demonstrate that shielding the vulnerable while allowing infections to spread among the wider population would not have been a viable public health strategy for COVID-19 and is unlikely to be effective for future pandemics.
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spelling pubmed-100212852023-03-17 Critical weaknesses in shielding strategies for COVID-19 Smith, Cameron A. Yates, Christian A. Ashby, Ben PLOS Glob Public Health Research Article The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to a wide range of non-pharmaceutical interventions being implemented around the world to curb transmission. However, the economic and social costs of some of these measures, especially lockdowns, has been high. An alternative and widely discussed public health strategy for the COVID-19 pandemic would have been to ‘shield’ those most vulnerable to COVID-19 (minimising their contacts with others), while allowing infection to spread among lower risk individuals with the aim of reaching herd immunity. Here we retrospectively explore the effectiveness of this strategy using a stochastic SEIR framework, showing that even under the unrealistic assumption of perfect shielding, hospitals would have been rapidly overwhelmed with many avoidable deaths among lower risk individuals. Crucially, even a small (20%) reduction in the effectiveness of shielding would have likely led to a large increase (>150%) in the number of deaths compared to perfect shielding. Our findings demonstrate that shielding the vulnerable while allowing infections to spread among the wider population would not have been a viable public health strategy for COVID-19 and is unlikely to be effective for future pandemics. Public Library of Science 2022-04-26 /pmc/articles/PMC10021285/ /pubmed/36962415 http://dx.doi.org/10.1371/journal.pgph.0000298 Text en © 2022 Smith et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Smith, Cameron A.
Yates, Christian A.
Ashby, Ben
Critical weaknesses in shielding strategies for COVID-19
title Critical weaknesses in shielding strategies for COVID-19
title_full Critical weaknesses in shielding strategies for COVID-19
title_fullStr Critical weaknesses in shielding strategies for COVID-19
title_full_unstemmed Critical weaknesses in shielding strategies for COVID-19
title_short Critical weaknesses in shielding strategies for COVID-19
title_sort critical weaknesses in shielding strategies for covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021285/
https://www.ncbi.nlm.nih.gov/pubmed/36962415
http://dx.doi.org/10.1371/journal.pgph.0000298
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