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Urban risk factors for human Rift Valley fever virus exposure in Kenya

The Rift Valley fever virus (RVFV) is a zoonotic arbovirus that can also transmit directly to humans from livestock. Previous studies have shown consumption of sick animal products are risk factors for RVFV infection, but it is difficult to disentangle those risk factors from other livestock rearing...

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Autores principales: Gerken, Keli Nicole, Mutuku, Francis Maluki, Ndenga, Bryson Alberto, Agola, Gladys Adhiambo, Migliore, Eleonora, Fabre, Eduardo Palacios, Malumbo, Said, Shaita, Karren Nyumbile, Rezende, Izabela Mauricio, LaBeaud, A. Desiree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021321/
https://www.ncbi.nlm.nih.gov/pubmed/36962424
http://dx.doi.org/10.1371/journal.pgph.0000505
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author Gerken, Keli Nicole
Mutuku, Francis Maluki
Ndenga, Bryson Alberto
Agola, Gladys Adhiambo
Migliore, Eleonora
Fabre, Eduardo Palacios
Malumbo, Said
Shaita, Karren Nyumbile
Rezende, Izabela Mauricio
LaBeaud, A. Desiree
author_facet Gerken, Keli Nicole
Mutuku, Francis Maluki
Ndenga, Bryson Alberto
Agola, Gladys Adhiambo
Migliore, Eleonora
Fabre, Eduardo Palacios
Malumbo, Said
Shaita, Karren Nyumbile
Rezende, Izabela Mauricio
LaBeaud, A. Desiree
author_sort Gerken, Keli Nicole
collection PubMed
description The Rift Valley fever virus (RVFV) is a zoonotic arbovirus that can also transmit directly to humans from livestock. Previous studies have shown consumption of sick animal products are risk factors for RVFV infection, but it is difficult to disentangle those risk factors from other livestock rearing activities. Urban areas have an increased demand for animal source foods, different vector distributions, and various arboviruses are understood to establish localized urban transmission cycles. Thus far, RVFV is an unevaluated public health risk in urban areas within endemic regions. We tested participants in our ongoing urban cohort study on dengue (DENV) and chikungunya (CHIKV) virus for RVFV exposure and found 1.6% (57/3,560) of individuals in two urban areas of Kenya had anti-RVFV IgG antibodies. 88% (50/57) of RVFV exposed participants also had antibodies to DENV, CHIKV, or both. Although livestock ownership was very low in urban study sites, RVFV exposure was overall significantly associated with seeing goats around the homestead (OR = 2.34 (CI 95%: 1.18–4.69, p = 0.02) and in Kisumu, RVFV exposure was associated with consumption of raw milk (OR = 6.28 (CI 95%: 0.94–25.21, p = 0.02). In addition, lack of piped water and use of small jugs (15–20 liters) for water was associated with a higher risk of RVFV exposure (OR = 5.36 (CI 95%: 1.23–16.44, p = 0.01) and this may contribute to interepidemic vector-borne maintenance of RVFV. We also investigated perception towards human vaccination for RVFV and identified high acceptance (91% (97/105) at our study sites. This study provides baseline evidence to guide future studies investigating the urban potential of RVFV and highlights the unexplored role of animal products in continued spread of RVFV.
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spelling pubmed-100213212023-03-17 Urban risk factors for human Rift Valley fever virus exposure in Kenya Gerken, Keli Nicole Mutuku, Francis Maluki Ndenga, Bryson Alberto Agola, Gladys Adhiambo Migliore, Eleonora Fabre, Eduardo Palacios Malumbo, Said Shaita, Karren Nyumbile Rezende, Izabela Mauricio LaBeaud, A. Desiree PLOS Glob Public Health Research Article The Rift Valley fever virus (RVFV) is a zoonotic arbovirus that can also transmit directly to humans from livestock. Previous studies have shown consumption of sick animal products are risk factors for RVFV infection, but it is difficult to disentangle those risk factors from other livestock rearing activities. Urban areas have an increased demand for animal source foods, different vector distributions, and various arboviruses are understood to establish localized urban transmission cycles. Thus far, RVFV is an unevaluated public health risk in urban areas within endemic regions. We tested participants in our ongoing urban cohort study on dengue (DENV) and chikungunya (CHIKV) virus for RVFV exposure and found 1.6% (57/3,560) of individuals in two urban areas of Kenya had anti-RVFV IgG antibodies. 88% (50/57) of RVFV exposed participants also had antibodies to DENV, CHIKV, or both. Although livestock ownership was very low in urban study sites, RVFV exposure was overall significantly associated with seeing goats around the homestead (OR = 2.34 (CI 95%: 1.18–4.69, p = 0.02) and in Kisumu, RVFV exposure was associated with consumption of raw milk (OR = 6.28 (CI 95%: 0.94–25.21, p = 0.02). In addition, lack of piped water and use of small jugs (15–20 liters) for water was associated with a higher risk of RVFV exposure (OR = 5.36 (CI 95%: 1.23–16.44, p = 0.01) and this may contribute to interepidemic vector-borne maintenance of RVFV. We also investigated perception towards human vaccination for RVFV and identified high acceptance (91% (97/105) at our study sites. This study provides baseline evidence to guide future studies investigating the urban potential of RVFV and highlights the unexplored role of animal products in continued spread of RVFV. Public Library of Science 2022-07-14 /pmc/articles/PMC10021321/ /pubmed/36962424 http://dx.doi.org/10.1371/journal.pgph.0000505 Text en © 2022 Gerken et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gerken, Keli Nicole
Mutuku, Francis Maluki
Ndenga, Bryson Alberto
Agola, Gladys Adhiambo
Migliore, Eleonora
Fabre, Eduardo Palacios
Malumbo, Said
Shaita, Karren Nyumbile
Rezende, Izabela Mauricio
LaBeaud, A. Desiree
Urban risk factors for human Rift Valley fever virus exposure in Kenya
title Urban risk factors for human Rift Valley fever virus exposure in Kenya
title_full Urban risk factors for human Rift Valley fever virus exposure in Kenya
title_fullStr Urban risk factors for human Rift Valley fever virus exposure in Kenya
title_full_unstemmed Urban risk factors for human Rift Valley fever virus exposure in Kenya
title_short Urban risk factors for human Rift Valley fever virus exposure in Kenya
title_sort urban risk factors for human rift valley fever virus exposure in kenya
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021321/
https://www.ncbi.nlm.nih.gov/pubmed/36962424
http://dx.doi.org/10.1371/journal.pgph.0000505
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