Cargando…

Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study

BACKGROUND: Simultaneous presence of elevated waist circumference and hypertriglyceridemia (HTGW) is a simple and low-cost measure of visceral obesity, and it is associated with a plethora of cardio-metabolic abnormalities that can increase the risk of cardiovascular diseases and incident Type 2 dia...

Descripción completa

Detalles Bibliográficos
Autores principales: Amadi, Casmir E., Mbakwem, Amam C., Duro, Dolapo C., Udenze, Ifeoma C., Akinsola, Clement M., Ajuluchukwu, Jayne N., Wale Oke, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021371/
https://www.ncbi.nlm.nih.gov/pubmed/36962833
http://dx.doi.org/10.1371/journal.pgph.0001203
_version_ 1784908469564866560
author Amadi, Casmir E.
Mbakwem, Amam C.
Duro, Dolapo C.
Udenze, Ifeoma C.
Akinsola, Clement M.
Ajuluchukwu, Jayne N.
Wale Oke, David A.
author_facet Amadi, Casmir E.
Mbakwem, Amam C.
Duro, Dolapo C.
Udenze, Ifeoma C.
Akinsola, Clement M.
Ajuluchukwu, Jayne N.
Wale Oke, David A.
author_sort Amadi, Casmir E.
collection PubMed
description BACKGROUND: Simultaneous presence of elevated waist circumference and hypertriglyceridemia (HTGW) is a simple and low-cost measure of visceral obesity, and it is associated with a plethora of cardio-metabolic abnormalities that can increase the risk of cardiovascular diseases and incident Type 2 diabetes mellitus. We decided to study the prevalence, patterns, and predictors of metabolic abnormalities in Nigerian hypertensives with the HTGW phenotype. METHODS: The medical records of 582 hypertensives with complete data of interest were retrieved and analyzed for the study. Their socio-demographic data, anthropometric data, and booking blood pressure values were retrieved. The results of their fasting plasma glucose, lipid profile, uric acid and serum creatinine were also retrieved for analysis. RESULTS: The mean age of the study population was 56.2 ±13.6, with 53.1% being males. The prevalence of smoking and use of alcohol was 4.3% and 26.5% respectively. The prevalence of the HTGW phenotype was 23.4% and were predominantly males (61%). Subjects with the HTGW phenotype were more obese assessed by waist circumference (WC) and body mass index (BMI). Mean serum total cholesterol, triglyceride, very low-density lipoprotein, uric acid, and creatinine were significantly higher in the HTGW phenotype (p = 0.003; <0.001; <0.001; 0.002 and <0.001 respectively). The prevalence of newly diagnosed Type 2 diabetes was 28.7%. There was also a preponderance of cardio-metabolic abnormalities (obesity, dyslipidaemia, hyperuricemia) in the HTGW phenotype. In both males and females, the HGTW phenotype was significantly associated with elevated Tc, TG, VLDL, hyperuricemia and atherogenic index of plasma. CONCLUSION: The HTGW phenotype is common amongst Nigerian hypertensives, and it is associated with metabolic abnormalities.
format Online
Article
Text
id pubmed-10021371
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-100213712023-03-17 Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study Amadi, Casmir E. Mbakwem, Amam C. Duro, Dolapo C. Udenze, Ifeoma C. Akinsola, Clement M. Ajuluchukwu, Jayne N. Wale Oke, David A. PLOS Glob Public Health Research Article BACKGROUND: Simultaneous presence of elevated waist circumference and hypertriglyceridemia (HTGW) is a simple and low-cost measure of visceral obesity, and it is associated with a plethora of cardio-metabolic abnormalities that can increase the risk of cardiovascular diseases and incident Type 2 diabetes mellitus. We decided to study the prevalence, patterns, and predictors of metabolic abnormalities in Nigerian hypertensives with the HTGW phenotype. METHODS: The medical records of 582 hypertensives with complete data of interest were retrieved and analyzed for the study. Their socio-demographic data, anthropometric data, and booking blood pressure values were retrieved. The results of their fasting plasma glucose, lipid profile, uric acid and serum creatinine were also retrieved for analysis. RESULTS: The mean age of the study population was 56.2 ±13.6, with 53.1% being males. The prevalence of smoking and use of alcohol was 4.3% and 26.5% respectively. The prevalence of the HTGW phenotype was 23.4% and were predominantly males (61%). Subjects with the HTGW phenotype were more obese assessed by waist circumference (WC) and body mass index (BMI). Mean serum total cholesterol, triglyceride, very low-density lipoprotein, uric acid, and creatinine were significantly higher in the HTGW phenotype (p = 0.003; <0.001; <0.001; 0.002 and <0.001 respectively). The prevalence of newly diagnosed Type 2 diabetes was 28.7%. There was also a preponderance of cardio-metabolic abnormalities (obesity, dyslipidaemia, hyperuricemia) in the HTGW phenotype. In both males and females, the HGTW phenotype was significantly associated with elevated Tc, TG, VLDL, hyperuricemia and atherogenic index of plasma. CONCLUSION: The HTGW phenotype is common amongst Nigerian hypertensives, and it is associated with metabolic abnormalities. Public Library of Science 2022-12-16 /pmc/articles/PMC10021371/ /pubmed/36962833 http://dx.doi.org/10.1371/journal.pgph.0001203 Text en © 2022 Amadi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Amadi, Casmir E.
Mbakwem, Amam C.
Duro, Dolapo C.
Udenze, Ifeoma C.
Akinsola, Clement M.
Ajuluchukwu, Jayne N.
Wale Oke, David A.
Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
title Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
title_full Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
title_fullStr Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
title_full_unstemmed Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
title_short Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
title_sort prevalence, patterns and predictors of metabolic abnormalities in nigerian hypertensives with hypertriglyceridemic waist phenotype: a cross sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021371/
https://www.ncbi.nlm.nih.gov/pubmed/36962833
http://dx.doi.org/10.1371/journal.pgph.0001203
work_keys_str_mv AT amadicasmire prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy
AT mbakwemamamc prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy
AT durodolapoc prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy
AT udenzeifeomac prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy
AT akinsolaclementm prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy
AT ajuluchukwujaynen prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy
AT waleokedavida prevalencepatternsandpredictorsofmetabolicabnormalitiesinnigerianhypertensiveswithhypertriglyceridemicwaistphenotypeacrosssectionalstudy