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Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses

Initial global-level estimates reported in June 2020 by the World Health Organization suggested that levels of disruption to TB service delivery could be as high as 25%-50% and result in an additional 6·3 million cases of tuberculosis (TB) and an additional 1·4 million TB-related deaths attributable...

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Autores principales: Martin-Hughes, Rowan, Vu, Lung, Cheikh, Nejma, Kelly, Sherrie L., Fraser-Hurt, Nicole, Shubber, Zara, Manhiça, Ivan, Mbendera, Kuzani, Girma, Belaineh, Pambudi, Imran, Ríos, Julia, Elmira, Abdrahmanova, Harimurti, Pandu, Hafez, Reem, Garcia, Jaime Nicolas Bayona, Palmer, Tom, Roberts, Anna, Gorgens, Marelize, Wilson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021439/
https://www.ncbi.nlm.nih.gov/pubmed/36962192
http://dx.doi.org/10.1371/journal.pgph.0000219
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author Martin-Hughes, Rowan
Vu, Lung
Cheikh, Nejma
Kelly, Sherrie L.
Fraser-Hurt, Nicole
Shubber, Zara
Manhiça, Ivan
Mbendera, Kuzani
Girma, Belaineh
Pambudi, Imran
Ríos, Julia
Elmira, Abdrahmanova
Harimurti, Pandu
Hafez, Reem
Garcia, Jaime Nicolas Bayona
Palmer, Tom
Roberts, Anna
Gorgens, Marelize
Wilson, David
author_facet Martin-Hughes, Rowan
Vu, Lung
Cheikh, Nejma
Kelly, Sherrie L.
Fraser-Hurt, Nicole
Shubber, Zara
Manhiça, Ivan
Mbendera, Kuzani
Girma, Belaineh
Pambudi, Imran
Ríos, Julia
Elmira, Abdrahmanova
Harimurti, Pandu
Hafez, Reem
Garcia, Jaime Nicolas Bayona
Palmer, Tom
Roberts, Anna
Gorgens, Marelize
Wilson, David
author_sort Martin-Hughes, Rowan
collection PubMed
description Initial global-level estimates reported in June 2020 by the World Health Organization suggested that levels of disruption to TB service delivery could be as high as 25%-50% and result in an additional 6·3 million cases of tuberculosis (TB) and an additional 1·4 million TB-related deaths attributable to COVID-19 between 2020 and 2025. Quarterly epidemiological estimates and programmatic TB data capturing disruption levels to each TB service were collected by National TB Programmes in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru. Data from 2019, for a pre-COVID-19 baseline, and throughout 2020, together with the NTP’s COVID-19 response plans, were used within Optima TB models to project TB incidence and deaths over five years because of COVID-19-related disruptions, and the extent to which those impacts may be mitigated through proposed catch-up strategies in each country. Countries reported disruptions of up to 64% to demand-driven TB diagnosis. However, TB service availability disruptions were shorter and less severe, with TB treatment experiencing levels of disruption of up to 21%. We predicted that under the worse-case scenario cumulative new latent TB infections, new active TB infections, and TB-related deaths could increase by up to 23%, 11%, and 20%, respectively, by 2024. However, three of the five countries were on track to mitigate these increases to 3% or less by maintaining TB services in 2021 and 2022 and by implementing proposed catch-up strategies. Indonesia was already experiencing the worse-case scenario, which could lead to 270,000 additional active TB infections and 36,000 additional TB-related deaths by the end of 2024. The COVID-19 pandemic is projected to negatively affect progress towards 2035 End TB targets, especially in countries already off-track. Findings highlight both successful TB service delivery adaptions in 2020 and the need to proactively maintain TB service availability despite potential future waves of more transmissible COVID-19 variants.
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spelling pubmed-100214392023-03-17 Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses Martin-Hughes, Rowan Vu, Lung Cheikh, Nejma Kelly, Sherrie L. Fraser-Hurt, Nicole Shubber, Zara Manhiça, Ivan Mbendera, Kuzani Girma, Belaineh Pambudi, Imran Ríos, Julia Elmira, Abdrahmanova Harimurti, Pandu Hafez, Reem Garcia, Jaime Nicolas Bayona Palmer, Tom Roberts, Anna Gorgens, Marelize Wilson, David PLOS Glob Public Health Research Article Initial global-level estimates reported in June 2020 by the World Health Organization suggested that levels of disruption to TB service delivery could be as high as 25%-50% and result in an additional 6·3 million cases of tuberculosis (TB) and an additional 1·4 million TB-related deaths attributable to COVID-19 between 2020 and 2025. Quarterly epidemiological estimates and programmatic TB data capturing disruption levels to each TB service were collected by National TB Programmes in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru. Data from 2019, for a pre-COVID-19 baseline, and throughout 2020, together with the NTP’s COVID-19 response plans, were used within Optima TB models to project TB incidence and deaths over five years because of COVID-19-related disruptions, and the extent to which those impacts may be mitigated through proposed catch-up strategies in each country. Countries reported disruptions of up to 64% to demand-driven TB diagnosis. However, TB service availability disruptions were shorter and less severe, with TB treatment experiencing levels of disruption of up to 21%. We predicted that under the worse-case scenario cumulative new latent TB infections, new active TB infections, and TB-related deaths could increase by up to 23%, 11%, and 20%, respectively, by 2024. However, three of the five countries were on track to mitigate these increases to 3% or less by maintaining TB services in 2021 and 2022 and by implementing proposed catch-up strategies. Indonesia was already experiencing the worse-case scenario, which could lead to 270,000 additional active TB infections and 36,000 additional TB-related deaths by the end of 2024. The COVID-19 pandemic is projected to negatively affect progress towards 2035 End TB targets, especially in countries already off-track. Findings highlight both successful TB service delivery adaptions in 2020 and the need to proactively maintain TB service availability despite potential future waves of more transmissible COVID-19 variants. Public Library of Science 2022-03-30 /pmc/articles/PMC10021439/ /pubmed/36962192 http://dx.doi.org/10.1371/journal.pgph.0000219 Text en © 2022 Martin-Hughes et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Martin-Hughes, Rowan
Vu, Lung
Cheikh, Nejma
Kelly, Sherrie L.
Fraser-Hurt, Nicole
Shubber, Zara
Manhiça, Ivan
Mbendera, Kuzani
Girma, Belaineh
Pambudi, Imran
Ríos, Julia
Elmira, Abdrahmanova
Harimurti, Pandu
Hafez, Reem
Garcia, Jaime Nicolas Bayona
Palmer, Tom
Roberts, Anna
Gorgens, Marelize
Wilson, David
Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses
title Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses
title_full Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses
title_fullStr Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses
title_full_unstemmed Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses
title_short Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: Implications for national TB responses
title_sort impacts of covid-19-related service disruptions on tb incidence and deaths in indonesia, kyrgyzstan, malawi, mozambique, and peru: implications for national tb responses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021439/
https://www.ncbi.nlm.nih.gov/pubmed/36962192
http://dx.doi.org/10.1371/journal.pgph.0000219
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