Cargando…

The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment

A saturated health care system with a lack of evidence-based antiviral medicine and ignorance of antimicrobial stewardship during pandemics has prompted clinicians to prescribe a broad-spectrum antibiotic more often. A prospective, cross-sectional study of COVID-infected patients was conducted to ga...

Descripción completa

Detalles Bibliográficos
Autores principales: Shrestha, Yogendra, Shivalingegowda, Ravi Kurikempannadoddi, Avinash, Melkote Jyotiprakash, Kenchegowda, Sharath Babu Hagalahalli, Moktan, Jeet Bahadur, Doddasamiah, Sreenivas Murthy, Tambat, Ramesh Mahadev, Golshetty, Deepanjali Girish, Ganesh, Vakkalagadda Siva, Venkataraman, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021591/
https://www.ncbi.nlm.nih.gov/pubmed/36962458
http://dx.doi.org/10.1371/journal.pgph.0000641
_version_ 1784908529683922944
author Shrestha, Yogendra
Shivalingegowda, Ravi Kurikempannadoddi
Avinash, Melkote Jyotiprakash
Kenchegowda, Sharath Babu Hagalahalli
Moktan, Jeet Bahadur
Doddasamiah, Sreenivas Murthy
Tambat, Ramesh Mahadev
Golshetty, Deepanjali Girish
Ganesh, Vakkalagadda Siva
Venkataraman, Rajesh
author_facet Shrestha, Yogendra
Shivalingegowda, Ravi Kurikempannadoddi
Avinash, Melkote Jyotiprakash
Kenchegowda, Sharath Babu Hagalahalli
Moktan, Jeet Bahadur
Doddasamiah, Sreenivas Murthy
Tambat, Ramesh Mahadev
Golshetty, Deepanjali Girish
Ganesh, Vakkalagadda Siva
Venkataraman, Rajesh
author_sort Shrestha, Yogendra
collection PubMed
description A saturated health care system with a lack of evidence-based antiviral medicine and ignorance of antimicrobial stewardship during pandemics has prompted clinicians to prescribe a broad-spectrum antibiotic more often. A prospective, cross-sectional study of COVID-infected patients was conducted to gain insight into antibiotic prescribing practices and their impact on antimicrobial resistance. The antibiotic susceptibility test was performed using the disc diffusion method. 318 patients met the study’s inclusion criteria, with a mean age of 46 years and 55% (175) of them being males. Antibiotics were prescribed for 93.72% (209) of mild cases, 92.45% (49) of moderate cases, 96.15% (25) of severe cases, and 100% (16) of critical cases of COVID-19. A total of 95 samples were sent in for culture and antibiotic sensitivity testing, with 58.95% (56) confirming growth. The majority of the growth was found to contain E. coli (14). In 54.9% of cases, antibiotics with less than 50% sensitivity to curing bacterial infection were detected. In the study, we found that antibiotics were being used unnecessarily in excessive quantities and that more than half of the antibiotics were less sensitive to isolated bacteria.
format Online
Article
Text
id pubmed-10021591
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-100215912023-03-17 The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment Shrestha, Yogendra Shivalingegowda, Ravi Kurikempannadoddi Avinash, Melkote Jyotiprakash Kenchegowda, Sharath Babu Hagalahalli Moktan, Jeet Bahadur Doddasamiah, Sreenivas Murthy Tambat, Ramesh Mahadev Golshetty, Deepanjali Girish Ganesh, Vakkalagadda Siva Venkataraman, Rajesh PLOS Glob Public Health Research Article A saturated health care system with a lack of evidence-based antiviral medicine and ignorance of antimicrobial stewardship during pandemics has prompted clinicians to prescribe a broad-spectrum antibiotic more often. A prospective, cross-sectional study of COVID-infected patients was conducted to gain insight into antibiotic prescribing practices and their impact on antimicrobial resistance. The antibiotic susceptibility test was performed using the disc diffusion method. 318 patients met the study’s inclusion criteria, with a mean age of 46 years and 55% (175) of them being males. Antibiotics were prescribed for 93.72% (209) of mild cases, 92.45% (49) of moderate cases, 96.15% (25) of severe cases, and 100% (16) of critical cases of COVID-19. A total of 95 samples were sent in for culture and antibiotic sensitivity testing, with 58.95% (56) confirming growth. The majority of the growth was found to contain E. coli (14). In 54.9% of cases, antibiotics with less than 50% sensitivity to curing bacterial infection were detected. In the study, we found that antibiotics were being used unnecessarily in excessive quantities and that more than half of the antibiotics were less sensitive to isolated bacteria. Public Library of Science 2022-07-13 /pmc/articles/PMC10021591/ /pubmed/36962458 http://dx.doi.org/10.1371/journal.pgph.0000641 Text en © 2022 Shrestha et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shrestha, Yogendra
Shivalingegowda, Ravi Kurikempannadoddi
Avinash, Melkote Jyotiprakash
Kenchegowda, Sharath Babu Hagalahalli
Moktan, Jeet Bahadur
Doddasamiah, Sreenivas Murthy
Tambat, Ramesh Mahadev
Golshetty, Deepanjali Girish
Ganesh, Vakkalagadda Siva
Venkataraman, Rajesh
The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment
title The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment
title_full The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment
title_fullStr The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment
title_full_unstemmed The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment
title_short The rise in antimicrobial resistance: An obscure issue in COVID-19 treatment
title_sort rise in antimicrobial resistance: an obscure issue in covid-19 treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021591/
https://www.ncbi.nlm.nih.gov/pubmed/36962458
http://dx.doi.org/10.1371/journal.pgph.0000641
work_keys_str_mv AT shresthayogendra theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT shivalingegowdaravikurikempannadoddi theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT avinashmelkotejyotiprakash theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT kenchegowdasharathbabuhagalahalli theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT moktanjeetbahadur theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT doddasamiahsreenivasmurthy theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT tambatrameshmahadev theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT golshettydeepanjaligirish theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT ganeshvakkalagaddasiva theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT venkataramanrajesh theriseinantimicrobialresistanceanobscureissueincovid19treatment
AT shresthayogendra riseinantimicrobialresistanceanobscureissueincovid19treatment
AT shivalingegowdaravikurikempannadoddi riseinantimicrobialresistanceanobscureissueincovid19treatment
AT avinashmelkotejyotiprakash riseinantimicrobialresistanceanobscureissueincovid19treatment
AT kenchegowdasharathbabuhagalahalli riseinantimicrobialresistanceanobscureissueincovid19treatment
AT moktanjeetbahadur riseinantimicrobialresistanceanobscureissueincovid19treatment
AT doddasamiahsreenivasmurthy riseinantimicrobialresistanceanobscureissueincovid19treatment
AT tambatrameshmahadev riseinantimicrobialresistanceanobscureissueincovid19treatment
AT golshettydeepanjaligirish riseinantimicrobialresistanceanobscureissueincovid19treatment
AT ganeshvakkalagaddasiva riseinantimicrobialresistanceanobscureissueincovid19treatment
AT venkataramanrajesh riseinantimicrobialresistanceanobscureissueincovid19treatment