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Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01(E) vaccination and BCG-revaccination-like candidates and...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021736/ https://www.ncbi.nlm.nih.gov/pubmed/36962104 http://dx.doi.org/10.1371/journal.pgph.0000076 |
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author | Pelzer, Puck T. Seeley, Janet Sun, Fiona Yueqian Tameris, Michele Tao, Li Yanlin, Zhao Moosan, Hisham Weerasuriya, Chathika Asaria, Miqdad Jayawardana, Sahan White, Richard G. Harris, Rebecca C. |
author_facet | Pelzer, Puck T. Seeley, Janet Sun, Fiona Yueqian Tameris, Michele Tao, Li Yanlin, Zhao Moosan, Hisham Weerasuriya, Chathika Asaria, Miqdad Jayawardana, Sahan White, Richard G. Harris, Rebecca C. |
author_sort | Pelzer, Puck T. |
collection | PubMed |
description | Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01(E) vaccination and BCG-revaccination-like candidates and explored their acceptability and feasibility. We conducted in-depth semi-structured interviews among key decision makers to identify implementation strategies and target groups in South Africa, India, and China. Thematic and deductive analysis using a coding framework were used to identify themes across and within settings. In all three countries there was interest in novel TB vaccines, with school-attending adolescents named as a likely target group. In China and India, older people were also identified as a target group. Routine vaccination was preferred in all countries due to stigma and logistical issues with targeted mass campaigns. Perceived benefits for implementation of M72/AS01(E) were the likely efficacy in individuals with Mycobacterium tuberculosis (Mtb) infection and efficacy for people living with HIV. Perceived challenges for M72/AS01(E) included the infrastructure and the two-dose regimen required. Stakeholders valued the familiarity of BCG but were concerned about the adverse effects in people living with HIV, a particular concern in South Africa. Implementation challenges and opportunities were identified in all three countries. Our study provides crucial information for implementing novel TB vaccines in specific target groups and on country specific acceptability and feasibility. Key groups for vaccine implementation in these settings were identified, and should be included in clinical trials and implementation planning. |
format | Online Article Text |
id | pubmed-10021736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-100217362023-03-17 Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines Pelzer, Puck T. Seeley, Janet Sun, Fiona Yueqian Tameris, Michele Tao, Li Yanlin, Zhao Moosan, Hisham Weerasuriya, Chathika Asaria, Miqdad Jayawardana, Sahan White, Richard G. Harris, Rebecca C. PLOS Glob Public Health Research Article Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01(E) vaccination and BCG-revaccination-like candidates and explored their acceptability and feasibility. We conducted in-depth semi-structured interviews among key decision makers to identify implementation strategies and target groups in South Africa, India, and China. Thematic and deductive analysis using a coding framework were used to identify themes across and within settings. In all three countries there was interest in novel TB vaccines, with school-attending adolescents named as a likely target group. In China and India, older people were also identified as a target group. Routine vaccination was preferred in all countries due to stigma and logistical issues with targeted mass campaigns. Perceived benefits for implementation of M72/AS01(E) were the likely efficacy in individuals with Mycobacterium tuberculosis (Mtb) infection and efficacy for people living with HIV. Perceived challenges for M72/AS01(E) included the infrastructure and the two-dose regimen required. Stakeholders valued the familiarity of BCG but were concerned about the adverse effects in people living with HIV, a particular concern in South Africa. Implementation challenges and opportunities were identified in all three countries. Our study provides crucial information for implementing novel TB vaccines in specific target groups and on country specific acceptability and feasibility. Key groups for vaccine implementation in these settings were identified, and should be included in clinical trials and implementation planning. Public Library of Science 2022-05-03 /pmc/articles/PMC10021736/ /pubmed/36962104 http://dx.doi.org/10.1371/journal.pgph.0000076 Text en © 2022 Pelzer et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Pelzer, Puck T. Seeley, Janet Sun, Fiona Yueqian Tameris, Michele Tao, Li Yanlin, Zhao Moosan, Hisham Weerasuriya, Chathika Asaria, Miqdad Jayawardana, Sahan White, Richard G. Harris, Rebecca C. Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines |
title | Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines |
title_full | Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines |
title_fullStr | Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines |
title_full_unstemmed | Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines |
title_short | Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines |
title_sort | potential implementation strategies, acceptability, and feasibility of new and repurposed tb vaccines |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021736/ https://www.ncbi.nlm.nih.gov/pubmed/36962104 http://dx.doi.org/10.1371/journal.pgph.0000076 |
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