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Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines

Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01(E) vaccination and BCG-revaccination-like candidates and...

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Autores principales: Pelzer, Puck T., Seeley, Janet, Sun, Fiona Yueqian, Tameris, Michele, Tao, Li, Yanlin, Zhao, Moosan, Hisham, Weerasuriya, Chathika, Asaria, Miqdad, Jayawardana, Sahan, White, Richard G., Harris, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021736/
https://www.ncbi.nlm.nih.gov/pubmed/36962104
http://dx.doi.org/10.1371/journal.pgph.0000076
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author Pelzer, Puck T.
Seeley, Janet
Sun, Fiona Yueqian
Tameris, Michele
Tao, Li
Yanlin, Zhao
Moosan, Hisham
Weerasuriya, Chathika
Asaria, Miqdad
Jayawardana, Sahan
White, Richard G.
Harris, Rebecca C.
author_facet Pelzer, Puck T.
Seeley, Janet
Sun, Fiona Yueqian
Tameris, Michele
Tao, Li
Yanlin, Zhao
Moosan, Hisham
Weerasuriya, Chathika
Asaria, Miqdad
Jayawardana, Sahan
White, Richard G.
Harris, Rebecca C.
author_sort Pelzer, Puck T.
collection PubMed
description Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01(E) vaccination and BCG-revaccination-like candidates and explored their acceptability and feasibility. We conducted in-depth semi-structured interviews among key decision makers to identify implementation strategies and target groups in South Africa, India, and China. Thematic and deductive analysis using a coding framework were used to identify themes across and within settings. In all three countries there was interest in novel TB vaccines, with school-attending adolescents named as a likely target group. In China and India, older people were also identified as a target group. Routine vaccination was preferred in all countries due to stigma and logistical issues with targeted mass campaigns. Perceived benefits for implementation of M72/AS01(E) were the likely efficacy in individuals with Mycobacterium tuberculosis (Mtb) infection and efficacy for people living with HIV. Perceived challenges for M72/AS01(E) included the infrastructure and the two-dose regimen required. Stakeholders valued the familiarity of BCG but were concerned about the adverse effects in people living with HIV, a particular concern in South Africa. Implementation challenges and opportunities were identified in all three countries. Our study provides crucial information for implementing novel TB vaccines in specific target groups and on country specific acceptability and feasibility. Key groups for vaccine implementation in these settings were identified, and should be included in clinical trials and implementation planning.
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spelling pubmed-100217362023-03-17 Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines Pelzer, Puck T. Seeley, Janet Sun, Fiona Yueqian Tameris, Michele Tao, Li Yanlin, Zhao Moosan, Hisham Weerasuriya, Chathika Asaria, Miqdad Jayawardana, Sahan White, Richard G. Harris, Rebecca C. PLOS Glob Public Health Research Article Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01(E) vaccination and BCG-revaccination-like candidates and explored their acceptability and feasibility. We conducted in-depth semi-structured interviews among key decision makers to identify implementation strategies and target groups in South Africa, India, and China. Thematic and deductive analysis using a coding framework were used to identify themes across and within settings. In all three countries there was interest in novel TB vaccines, with school-attending adolescents named as a likely target group. In China and India, older people were also identified as a target group. Routine vaccination was preferred in all countries due to stigma and logistical issues with targeted mass campaigns. Perceived benefits for implementation of M72/AS01(E) were the likely efficacy in individuals with Mycobacterium tuberculosis (Mtb) infection and efficacy for people living with HIV. Perceived challenges for M72/AS01(E) included the infrastructure and the two-dose regimen required. Stakeholders valued the familiarity of BCG but were concerned about the adverse effects in people living with HIV, a particular concern in South Africa. Implementation challenges and opportunities were identified in all three countries. Our study provides crucial information for implementing novel TB vaccines in specific target groups and on country specific acceptability and feasibility. Key groups for vaccine implementation in these settings were identified, and should be included in clinical trials and implementation planning. Public Library of Science 2022-05-03 /pmc/articles/PMC10021736/ /pubmed/36962104 http://dx.doi.org/10.1371/journal.pgph.0000076 Text en © 2022 Pelzer et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pelzer, Puck T.
Seeley, Janet
Sun, Fiona Yueqian
Tameris, Michele
Tao, Li
Yanlin, Zhao
Moosan, Hisham
Weerasuriya, Chathika
Asaria, Miqdad
Jayawardana, Sahan
White, Richard G.
Harris, Rebecca C.
Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
title Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
title_full Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
title_fullStr Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
title_full_unstemmed Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
title_short Potential implementation strategies, acceptability, and feasibility of new and repurposed TB vaccines
title_sort potential implementation strategies, acceptability, and feasibility of new and repurposed tb vaccines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021736/
https://www.ncbi.nlm.nih.gov/pubmed/36962104
http://dx.doi.org/10.1371/journal.pgph.0000076
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