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Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study

High prevalence of infectious tuberculosis among men suggests potential population-wide benefits from addressing programmatic and social determinants of gender disparities. Utilising a sex-stratified compartmental transmission model calibrated to tuberculosis burden estimates for Viet Nam, we modell...

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Autores principales: Horton, Katherine C., White, Richard G., Hoa, Nguyen Binh, Nguyen, Hai Viet, Bakker, Roel, Sumner, Tom, Corbett, Elizabeth L., Houben, Rein M. G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021793/
https://www.ncbi.nlm.nih.gov/pubmed/36962475
http://dx.doi.org/10.1371/journal.pgph.0000784
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author Horton, Katherine C.
White, Richard G.
Hoa, Nguyen Binh
Nguyen, Hai Viet
Bakker, Roel
Sumner, Tom
Corbett, Elizabeth L.
Houben, Rein M. G. J.
author_facet Horton, Katherine C.
White, Richard G.
Hoa, Nguyen Binh
Nguyen, Hai Viet
Bakker, Roel
Sumner, Tom
Corbett, Elizabeth L.
Houben, Rein M. G. J.
author_sort Horton, Katherine C.
collection PubMed
description High prevalence of infectious tuberculosis among men suggests potential population-wide benefits from addressing programmatic and social determinants of gender disparities. Utilising a sex-stratified compartmental transmission model calibrated to tuberculosis burden estimates for Viet Nam, we modelled interventions to increase active case finding, to reduce tobacco smoking, and to reduce alcohol consumption by 2025 in line with national and global targets. For each intervention, we examined scenarios differentially targeting men and women and evaluated impact on tuberculosis morbidity and mortality in men, women, and children in 2035. Active case finding interventions targeting men projected greater reductions in tuberculosis incidence in men, women, and children (16.2%, uncertainty interval, UI, 11.4–23.0%, 11.8%, UI 8.0–18.6%, and 21.5%, UI 16.9–28.5%, respectively) than those targeting women (5.2%, UI 3.8–7.1%, 5.4%, UI 3.9–7.3%, and 8.6%, UI 6.9–10.7%, respectively). Projected reductions in tuberculosis incidence for interventions to reduce male tobacco smoking and alcohol consumption were greatest for men (17.4%, UI 11.8–24.7%, and 11.0%, UI 5.4–19.4%, respectively), but still substantial for women (6.9%, UI 3.8–12.5%, and 4.4%, UI 1.9–10.6%, respectively) and children (12.7%, UI 8.4–19.0%, and 8.0%, UI 3.9–15.0%, respectively). Comparable interventions targeting women projected limited impact, with declines of 0.3% (UI 0.2%-0.3%) and 0.1% (UI 0.0%-0.1%), respectively. Addressing programmatic and social determinants of men’s tuberculosis burden has population-wide benefits. Future interventions to increase active case finding, to reduce tobacco smoking, and to reduce harmful alcohol consumption, whilst not ignoring women, should focus on men to most effectively reduce tuberculosis morbidity and mortality in men, women, and children.
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spelling pubmed-100217932023-03-17 Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study Horton, Katherine C. White, Richard G. Hoa, Nguyen Binh Nguyen, Hai Viet Bakker, Roel Sumner, Tom Corbett, Elizabeth L. Houben, Rein M. G. J. PLOS Glob Public Health Research Article High prevalence of infectious tuberculosis among men suggests potential population-wide benefits from addressing programmatic and social determinants of gender disparities. Utilising a sex-stratified compartmental transmission model calibrated to tuberculosis burden estimates for Viet Nam, we modelled interventions to increase active case finding, to reduce tobacco smoking, and to reduce alcohol consumption by 2025 in line with national and global targets. For each intervention, we examined scenarios differentially targeting men and women and evaluated impact on tuberculosis morbidity and mortality in men, women, and children in 2035. Active case finding interventions targeting men projected greater reductions in tuberculosis incidence in men, women, and children (16.2%, uncertainty interval, UI, 11.4–23.0%, 11.8%, UI 8.0–18.6%, and 21.5%, UI 16.9–28.5%, respectively) than those targeting women (5.2%, UI 3.8–7.1%, 5.4%, UI 3.9–7.3%, and 8.6%, UI 6.9–10.7%, respectively). Projected reductions in tuberculosis incidence for interventions to reduce male tobacco smoking and alcohol consumption were greatest for men (17.4%, UI 11.8–24.7%, and 11.0%, UI 5.4–19.4%, respectively), but still substantial for women (6.9%, UI 3.8–12.5%, and 4.4%, UI 1.9–10.6%, respectively) and children (12.7%, UI 8.4–19.0%, and 8.0%, UI 3.9–15.0%, respectively). Comparable interventions targeting women projected limited impact, with declines of 0.3% (UI 0.2%-0.3%) and 0.1% (UI 0.0%-0.1%), respectively. Addressing programmatic and social determinants of men’s tuberculosis burden has population-wide benefits. Future interventions to increase active case finding, to reduce tobacco smoking, and to reduce harmful alcohol consumption, whilst not ignoring women, should focus on men to most effectively reduce tuberculosis morbidity and mortality in men, women, and children. Public Library of Science 2022-07-14 /pmc/articles/PMC10021793/ /pubmed/36962475 http://dx.doi.org/10.1371/journal.pgph.0000784 Text en © 2022 Horton et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Horton, Katherine C.
White, Richard G.
Hoa, Nguyen Binh
Nguyen, Hai Viet
Bakker, Roel
Sumner, Tom
Corbett, Elizabeth L.
Houben, Rein M. G. J.
Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study
title Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study
title_full Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study
title_fullStr Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study
title_full_unstemmed Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study
title_short Population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in Viet Nam: A modelling study
title_sort population benefits of addressing programmatic and social determinants of gender disparities in tuberculosis in viet nam: a modelling study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021793/
https://www.ncbi.nlm.nih.gov/pubmed/36962475
http://dx.doi.org/10.1371/journal.pgph.0000784
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