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Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017

The burden of neonatal mortality remains high worldwide, particularly in South Asia. Verbal Autopsy is a method used to identify cause of death (COD) where vital registration capabilities are lacking. This study examines the causes of neonatal mortality in a large study population in rural Southern...

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Autores principales: Saya, Ayesha R., Katz, Joanne, Khatry, Subarna K., Tielsch, James M., LeClerq, Steven C., Mullany, Luke C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021801/
https://www.ncbi.nlm.nih.gov/pubmed/36962665
http://dx.doi.org/10.1371/journal.pgph.0001072
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author Saya, Ayesha R.
Katz, Joanne
Khatry, Subarna K.
Tielsch, James M.
LeClerq, Steven C.
Mullany, Luke C.
author_facet Saya, Ayesha R.
Katz, Joanne
Khatry, Subarna K.
Tielsch, James M.
LeClerq, Steven C.
Mullany, Luke C.
author_sort Saya, Ayesha R.
collection PubMed
description The burden of neonatal mortality remains high worldwide, particularly in South Asia. Verbal Autopsy is a method used to identify cause of death (COD) where vital registration capabilities are lacking. This study examines the causes of neonatal mortality in a large study population in rural Southern Nepal. The data used is from a larger cluster-randomized community-based trial. The study includes 984 neonatal deaths with complete verbal autopsy information which occurred between 2010 and 2017. The InterVA-5 software was used to identify COD. COD included severe infection (sepsis, pneumonia, meningitis/encephalitis), intrapartum related events (identified as birth asphyxia), congenital malformations, and other. The neonatal mortality rate was 31.2 neonatal deaths per 1000 live births. The causes of neonatal mortality were identified as prematurity (40%), intrapartum related events (35%), severe infection (19%), congenital abnormalities (4%), and other (2%). A high proportion, 42.5% of neonatal deaths occurred in the first 24 hours after birth. Over half (56.4%) of deaths occurred at home. This large prospective study identifies population level neonatal causes of death in rural Southern Nepal, which can contribute to national and regional COD estimates. Interventions to decrease neonatal mortality should focus on preventative measures and ensuring the delivery of high risk infants at a healthcare facility in the presence of a skilled birth attendant.
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spelling pubmed-100218012023-03-17 Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017 Saya, Ayesha R. Katz, Joanne Khatry, Subarna K. Tielsch, James M. LeClerq, Steven C. Mullany, Luke C. PLOS Glob Public Health Research Article The burden of neonatal mortality remains high worldwide, particularly in South Asia. Verbal Autopsy is a method used to identify cause of death (COD) where vital registration capabilities are lacking. This study examines the causes of neonatal mortality in a large study population in rural Southern Nepal. The data used is from a larger cluster-randomized community-based trial. The study includes 984 neonatal deaths with complete verbal autopsy information which occurred between 2010 and 2017. The InterVA-5 software was used to identify COD. COD included severe infection (sepsis, pneumonia, meningitis/encephalitis), intrapartum related events (identified as birth asphyxia), congenital malformations, and other. The neonatal mortality rate was 31.2 neonatal deaths per 1000 live births. The causes of neonatal mortality were identified as prematurity (40%), intrapartum related events (35%), severe infection (19%), congenital abnormalities (4%), and other (2%). A high proportion, 42.5% of neonatal deaths occurred in the first 24 hours after birth. Over half (56.4%) of deaths occurred at home. This large prospective study identifies population level neonatal causes of death in rural Southern Nepal, which can contribute to national and regional COD estimates. Interventions to decrease neonatal mortality should focus on preventative measures and ensuring the delivery of high risk infants at a healthcare facility in the presence of a skilled birth attendant. Public Library of Science 2022-09-15 /pmc/articles/PMC10021801/ /pubmed/36962665 http://dx.doi.org/10.1371/journal.pgph.0001072 Text en © 2022 Saya et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Saya, Ayesha R.
Katz, Joanne
Khatry, Subarna K.
Tielsch, James M.
LeClerq, Steven C.
Mullany, Luke C.
Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017
title Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017
title_full Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017
title_fullStr Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017
title_full_unstemmed Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017
title_short Causes of neonatal mortality using verbal autopsies in rural Southern Nepal, 2010–2017
title_sort causes of neonatal mortality using verbal autopsies in rural southern nepal, 2010–2017
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021801/
https://www.ncbi.nlm.nih.gov/pubmed/36962665
http://dx.doi.org/10.1371/journal.pgph.0001072
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