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Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals

Quantifying the costs of hospital associated infections (HAIs) caused by carbapenem-resistant Enterobacterales (CRE) can aid hospital decision makers in infection prevention and control decisions. We estimate the costs of a CRE HAI by infection type and the annual costs of CRE HAIs to acute-care hos...

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Autores principales: Cai, Yiying, Hoo, Grace S. R., Lee, Winnie, Tan, Ban Hock, Yoong, Joanne, Teo, Yik-Ying, Graves, Nicholas, Lye, David, Kwa, Andrea L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021918/
https://www.ncbi.nlm.nih.gov/pubmed/36962882
http://dx.doi.org/10.1371/journal.pgph.0001311
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author Cai, Yiying
Hoo, Grace S. R.
Lee, Winnie
Tan, Ban Hock
Yoong, Joanne
Teo, Yik-Ying
Graves, Nicholas
Lye, David
Kwa, Andrea L.
author_facet Cai, Yiying
Hoo, Grace S. R.
Lee, Winnie
Tan, Ban Hock
Yoong, Joanne
Teo, Yik-Ying
Graves, Nicholas
Lye, David
Kwa, Andrea L.
author_sort Cai, Yiying
collection PubMed
description Quantifying the costs of hospital associated infections (HAIs) caused by carbapenem-resistant Enterobacterales (CRE) can aid hospital decision makers in infection prevention and control decisions. We estimate the costs of a CRE HAI by infection type and the annual costs of CRE HAIs to acute-care hospitals in Singapore. We used tree diagrams to estimate the costs (in Singapore dollar) of different CRE HAI types from the health service perspective and compared them to the costs of carbapenem-susceptible HAIs. We used two approaches to estimate costs–direct costs of consumables for infection prevention and treatment; and costs associated with lost bed days. Cost of a HAI were extrapolated to annual CRE HAI incidence in Singapore acute-care hospitals to estimate the annual cost to the hospitals. We found that the cost of a CRE HAI based on direct cost and lost bed days are SGD$9,913 (95% CI, SGD$9,431–10,395) and SGD$10,044 (95% CI, SGD$9,789–10,300) respectively. CRE HAIs are markedly higher than the carbapenem-susceptible HAIs for all infection types. In both approaches, CRE pneumonia was the costliest infection. Based on a CRE HAI incidence of 233 per 100,000 inpatient admissions, CRE HAIs costed SGD$12.16M (95% CI, SGD$11.84–12.48M) annually based on direct costs, and SGD$12.33M (95% CI, SGD$12.01–12.64M) annually based on lost bed days. In conclusion, we described the cost of CRE HAIs in Singapore hospitals and identified infections with the highest costs. The findings may be useful in informing future economic evaluations of competing CRE HAI prevention and treatment programmes.
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spelling pubmed-100219182023-03-17 Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals Cai, Yiying Hoo, Grace S. R. Lee, Winnie Tan, Ban Hock Yoong, Joanne Teo, Yik-Ying Graves, Nicholas Lye, David Kwa, Andrea L. PLOS Glob Public Health Research Article Quantifying the costs of hospital associated infections (HAIs) caused by carbapenem-resistant Enterobacterales (CRE) can aid hospital decision makers in infection prevention and control decisions. We estimate the costs of a CRE HAI by infection type and the annual costs of CRE HAIs to acute-care hospitals in Singapore. We used tree diagrams to estimate the costs (in Singapore dollar) of different CRE HAI types from the health service perspective and compared them to the costs of carbapenem-susceptible HAIs. We used two approaches to estimate costs–direct costs of consumables for infection prevention and treatment; and costs associated with lost bed days. Cost of a HAI were extrapolated to annual CRE HAI incidence in Singapore acute-care hospitals to estimate the annual cost to the hospitals. We found that the cost of a CRE HAI based on direct cost and lost bed days are SGD$9,913 (95% CI, SGD$9,431–10,395) and SGD$10,044 (95% CI, SGD$9,789–10,300) respectively. CRE HAIs are markedly higher than the carbapenem-susceptible HAIs for all infection types. In both approaches, CRE pneumonia was the costliest infection. Based on a CRE HAI incidence of 233 per 100,000 inpatient admissions, CRE HAIs costed SGD$12.16M (95% CI, SGD$11.84–12.48M) annually based on direct costs, and SGD$12.33M (95% CI, SGD$12.01–12.64M) annually based on lost bed days. In conclusion, we described the cost of CRE HAIs in Singapore hospitals and identified infections with the highest costs. The findings may be useful in informing future economic evaluations of competing CRE HAI prevention and treatment programmes. Public Library of Science 2022-12-07 /pmc/articles/PMC10021918/ /pubmed/36962882 http://dx.doi.org/10.1371/journal.pgph.0001311 Text en © 2022 Cai et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cai, Yiying
Hoo, Grace S. R.
Lee, Winnie
Tan, Ban Hock
Yoong, Joanne
Teo, Yik-Ying
Graves, Nicholas
Lye, David
Kwa, Andrea L.
Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
title Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
title_full Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
title_fullStr Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
title_full_unstemmed Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
title_short Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
title_sort estimating the economic cost of carbapenem resistant enterobacterales healthcare associated infections in singapore acute-care hospitals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021918/
https://www.ncbi.nlm.nih.gov/pubmed/36962882
http://dx.doi.org/10.1371/journal.pgph.0001311
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