Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway

BACKGROUND: Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSC(ATV)-EV) have a superior cardiac repair effect on acute myocardial infarction (AMI). The mechanisms, however, have not been fully elucidated. This study aims to exp...

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Detalles Bibliográficos
Autores principales: Ning, Yu, Huang, Peisen, Chen, Guihao, Xiong, Yuyan, Gong, Zhaoting, Wu, Chunxiao, Xu, Junyan, Jiang, Wenyang, Li, Xiaosong, Tang, Ruijie, Zhang, Lili, Hu, Mengjin, Xu, Jing, Xu, Jun, Qian, Haiyan, Jin, Chen, Yang, Yuejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022054/
https://www.ncbi.nlm.nih.gov/pubmed/36927608
http://dx.doi.org/10.1186/s12916-023-02778-x

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