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Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018

There is limited surveillance and laboratory capacity for non-influenza respiratory viruses in India. We leveraged the influenza sentinel surveillance of India to detect other respiratory viruses among patients with acute respiratory infection. Six centers representing different geographic areas of...

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Autores principales: Chadha, Mandeep, Prabhakaran, Aslesh Ottapura, Choudhary, Manohar Lal, Biswas, Dipankar, Koul, Parvaiz, Kaveri, K., Dar, Lalit, Mamta, Chawla Sarkar, Jadhav, Santosh, Bhardwaj, Sumit Dutt, Laserson, Kayla, Saha, Siddhartha, Potdar, Varsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022084/
https://www.ncbi.nlm.nih.gov/pubmed/36962617
http://dx.doi.org/10.1371/journal.pgph.0001001
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author Chadha, Mandeep
Prabhakaran, Aslesh Ottapura
Choudhary, Manohar Lal
Biswas, Dipankar
Koul, Parvaiz
Kaveri, K.
Dar, Lalit
Mamta, Chawla Sarkar
Jadhav, Santosh
Bhardwaj, Sumit Dutt
Laserson, Kayla
Saha, Siddhartha
Potdar, Varsha
author_facet Chadha, Mandeep
Prabhakaran, Aslesh Ottapura
Choudhary, Manohar Lal
Biswas, Dipankar
Koul, Parvaiz
Kaveri, K.
Dar, Lalit
Mamta, Chawla Sarkar
Jadhav, Santosh
Bhardwaj, Sumit Dutt
Laserson, Kayla
Saha, Siddhartha
Potdar, Varsha
author_sort Chadha, Mandeep
collection PubMed
description There is limited surveillance and laboratory capacity for non-influenza respiratory viruses in India. We leveraged the influenza sentinel surveillance of India to detect other respiratory viruses among patients with acute respiratory infection. Six centers representing different geographic areas of India weekly enrolled a convenience sample of 5–10 patients with acute respiratory infection (ARI) and severe acute respiratory infection (SARI) between September 2016-December 2018. Staff collected nasal and throat specimens in viral transport medium and tested for influenza virus, respiratory syncytial virus (RSV), parainfluenza virus (PIV), human meta-pneumovirus (HMPV), adenovirus (AdV) and human rhinovirus (HRV) by reverse transcription polymerase chain reaction (RT-PCR). Phylogenetic analysis of influenza and RSV was done. We enrolled 16,338 including 8,947 ARI and 7,391 SARI cases during the study period. Median age was 14.6 years (IQR:4–32) in ARI cases and 13 years (IQR:1.3–55) in SARI cases. We detected respiratory viruses in 33.3% (2,981) of ARI and 33.4% (2,468) of SARI cases. Multiple viruses were co-detected in 2.8% (458/16,338) specimens. Among ARI cases influenza (15.4%) were the most frequently detected viruses followed by HRV (6.2%), RSV (5%), HMPV (3.4%), PIV (3.3%) and AdV (3.1%),. Similarly among SARI cases, influenza (12.7%) were most frequently detected followed by RSV (8.2%), HRV (6.1%), PIV (4%), HMPV (2.6%) and AdV (2.1%). Our study demonstrated the feasibility of expanding influenza surveillance systems for surveillance of other respiratory viruses in India. Influenza was the most detected virus among ARI and SARI cases.
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spelling pubmed-100220842023-03-17 Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018 Chadha, Mandeep Prabhakaran, Aslesh Ottapura Choudhary, Manohar Lal Biswas, Dipankar Koul, Parvaiz Kaveri, K. Dar, Lalit Mamta, Chawla Sarkar Jadhav, Santosh Bhardwaj, Sumit Dutt Laserson, Kayla Saha, Siddhartha Potdar, Varsha PLOS Glob Public Health Research Article There is limited surveillance and laboratory capacity for non-influenza respiratory viruses in India. We leveraged the influenza sentinel surveillance of India to detect other respiratory viruses among patients with acute respiratory infection. Six centers representing different geographic areas of India weekly enrolled a convenience sample of 5–10 patients with acute respiratory infection (ARI) and severe acute respiratory infection (SARI) between September 2016-December 2018. Staff collected nasal and throat specimens in viral transport medium and tested for influenza virus, respiratory syncytial virus (RSV), parainfluenza virus (PIV), human meta-pneumovirus (HMPV), adenovirus (AdV) and human rhinovirus (HRV) by reverse transcription polymerase chain reaction (RT-PCR). Phylogenetic analysis of influenza and RSV was done. We enrolled 16,338 including 8,947 ARI and 7,391 SARI cases during the study period. Median age was 14.6 years (IQR:4–32) in ARI cases and 13 years (IQR:1.3–55) in SARI cases. We detected respiratory viruses in 33.3% (2,981) of ARI and 33.4% (2,468) of SARI cases. Multiple viruses were co-detected in 2.8% (458/16,338) specimens. Among ARI cases influenza (15.4%) were the most frequently detected viruses followed by HRV (6.2%), RSV (5%), HMPV (3.4%), PIV (3.3%) and AdV (3.1%),. Similarly among SARI cases, influenza (12.7%) were most frequently detected followed by RSV (8.2%), HRV (6.1%), PIV (4%), HMPV (2.6%) and AdV (2.1%). Our study demonstrated the feasibility of expanding influenza surveillance systems for surveillance of other respiratory viruses in India. Influenza was the most detected virus among ARI and SARI cases. Public Library of Science 2022-11-04 /pmc/articles/PMC10022084/ /pubmed/36962617 http://dx.doi.org/10.1371/journal.pgph.0001001 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Chadha, Mandeep
Prabhakaran, Aslesh Ottapura
Choudhary, Manohar Lal
Biswas, Dipankar
Koul, Parvaiz
Kaveri, K.
Dar, Lalit
Mamta, Chawla Sarkar
Jadhav, Santosh
Bhardwaj, Sumit Dutt
Laserson, Kayla
Saha, Siddhartha
Potdar, Varsha
Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018
title Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018
title_full Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018
title_fullStr Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018
title_full_unstemmed Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018
title_short Multisite surveillance for influenza and other respiratory viruses in India: 2016–2018
title_sort multisite surveillance for influenza and other respiratory viruses in india: 2016–2018
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022084/
https://www.ncbi.nlm.nih.gov/pubmed/36962617
http://dx.doi.org/10.1371/journal.pgph.0001001
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