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Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus associated with coronavirus disease (COVID-19). At the time of the study, little data on the level of exposure of the population in Koutiala district in Mali to SARS-CoV-2 was available. Although blood donors are not represent...

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Autores principales: Temessadouno, Fara Wagbo, Ndong, Jean Gilbert, Gignoux, Etienne, Coppieters, Yves, Ba, Alhassane, Sidibe, Youssouf Diam, Daou, Aminata, Malou, Nada, Compaore, Idrissa, Fane, Tidiani, Simons, Erica, Luquero, Francisco, Mills, Clair, Vuti, Komla Mawunya, Nkokolo massamba, Marie Hortense, Guiramand, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022217/
https://www.ncbi.nlm.nih.gov/pubmed/36962828
http://dx.doi.org/10.1371/journal.pgph.0001316
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author Temessadouno, Fara Wagbo
Ndong, Jean Gilbert
Gignoux, Etienne
Coppieters, Yves
Ba, Alhassane
Sidibe, Youssouf Diam
Daou, Aminata
Malou, Nada
Compaore, Idrissa
Fane, Tidiani
Simons, Erica
Luquero, Francisco
Mills, Clair
Vuti, Komla Mawunya
Nkokolo massamba, Marie Hortense
Guiramand, Sonia
author_facet Temessadouno, Fara Wagbo
Ndong, Jean Gilbert
Gignoux, Etienne
Coppieters, Yves
Ba, Alhassane
Sidibe, Youssouf Diam
Daou, Aminata
Malou, Nada
Compaore, Idrissa
Fane, Tidiani
Simons, Erica
Luquero, Francisco
Mills, Clair
Vuti, Komla Mawunya
Nkokolo massamba, Marie Hortense
Guiramand, Sonia
author_sort Temessadouno, Fara Wagbo
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus associated with coronavirus disease (COVID-19). At the time of the study, little data on the level of exposure of the population in Koutiala district in Mali to SARS-CoV-2 was available. Although blood donors are not representative of the general population, a COVID-19 seroprevalence estimate in this population was intended to assess the extent of community transmission, serve as a health alert system, and help guide the public health response. We measured seroprevalence of anti-SARS-CoV-2 antibodies using NG-Biotech SARS-Cov-2 RDT and ECLIA test between January and June 2020. This is a cross-sectional study of volunteer blood donors aged 18 to 60 years, independent of any previous COVID-19 disease. A stratified analysis of seroprevalence by month of sample collection and a comparison of the results of the NG-Biotech SARS-Cov-2 RDT with those of the ECLIA test was performed. The overall prevalence of antibodies to SARS-Cov-2 virus assessed by the NG-Biotech SARS-Cov-2 RDT was 24.6% (95% CI 21.8–27.4) and by the ECLIA test was 70.2 (95% CI 64.9–75.5). Both estimates remained relatively stable over the study period. We observed SARS-CoV-2 exposure much higher than indicated by case-based surveillance. The national surveillance system, as it was, was not able to detect variations in incidence, and as such, we do not recommend it as an alert system. However, the discrepancy between the results of the rapid test and the ECLIA test shows that further research is required to assess the validity of these test before a more solid conclusion can be drawn it their use in surveillance.
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spelling pubmed-100222172023-03-17 Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali Temessadouno, Fara Wagbo Ndong, Jean Gilbert Gignoux, Etienne Coppieters, Yves Ba, Alhassane Sidibe, Youssouf Diam Daou, Aminata Malou, Nada Compaore, Idrissa Fane, Tidiani Simons, Erica Luquero, Francisco Mills, Clair Vuti, Komla Mawunya Nkokolo massamba, Marie Hortense Guiramand, Sonia PLOS Glob Public Health Research Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus associated with coronavirus disease (COVID-19). At the time of the study, little data on the level of exposure of the population in Koutiala district in Mali to SARS-CoV-2 was available. Although blood donors are not representative of the general population, a COVID-19 seroprevalence estimate in this population was intended to assess the extent of community transmission, serve as a health alert system, and help guide the public health response. We measured seroprevalence of anti-SARS-CoV-2 antibodies using NG-Biotech SARS-Cov-2 RDT and ECLIA test between January and June 2020. This is a cross-sectional study of volunteer blood donors aged 18 to 60 years, independent of any previous COVID-19 disease. A stratified analysis of seroprevalence by month of sample collection and a comparison of the results of the NG-Biotech SARS-Cov-2 RDT with those of the ECLIA test was performed. The overall prevalence of antibodies to SARS-Cov-2 virus assessed by the NG-Biotech SARS-Cov-2 RDT was 24.6% (95% CI 21.8–27.4) and by the ECLIA test was 70.2 (95% CI 64.9–75.5). Both estimates remained relatively stable over the study period. We observed SARS-CoV-2 exposure much higher than indicated by case-based surveillance. The national surveillance system, as it was, was not able to detect variations in incidence, and as such, we do not recommend it as an alert system. However, the discrepancy between the results of the rapid test and the ECLIA test shows that further research is required to assess the validity of these test before a more solid conclusion can be drawn it their use in surveillance. Public Library of Science 2023-01-05 /pmc/articles/PMC10022217/ /pubmed/36962828 http://dx.doi.org/10.1371/journal.pgph.0001316 Text en © 2023 Temessadouno et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Temessadouno, Fara Wagbo
Ndong, Jean Gilbert
Gignoux, Etienne
Coppieters, Yves
Ba, Alhassane
Sidibe, Youssouf Diam
Daou, Aminata
Malou, Nada
Compaore, Idrissa
Fane, Tidiani
Simons, Erica
Luquero, Francisco
Mills, Clair
Vuti, Komla Mawunya
Nkokolo massamba, Marie Hortense
Guiramand, Sonia
Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali
title Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali
title_full Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali
title_fullStr Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali
title_full_unstemmed Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali
title_short Seroprevalence of anti-SARS-CoV-2 antibodies among blood donors from December 2020 to June 2021 in Koutiala district, Mali
title_sort seroprevalence of anti-sars-cov-2 antibodies among blood donors from december 2020 to june 2021 in koutiala district, mali
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022217/
https://www.ncbi.nlm.nih.gov/pubmed/36962828
http://dx.doi.org/10.1371/journal.pgph.0001316
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