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Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017

Communicable diseases, alone or in combination with malnutrition, account for most deaths in complex emergencies including refugee settings. Tuberculosis and HIV/AIDS are increasingly becoming an important cause of morbidity and mortality in refugee settings. We described the treatment outcomes of T...

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Autores principales: Nguna, Joyce, Okethwangu, Denis, Kabwama, Steven Ndugwa, Aliddeki, Dativa Maria, Kironde, Susan Kizito, Birungi, Doreen, Eurien, Daniel, Ario, Alex Riolexus, Lukoye, Deus, Kasozi, Julius, Cegielski, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022256/
https://www.ncbi.nlm.nih.gov/pubmed/36962487
http://dx.doi.org/10.1371/journal.pgph.0000152
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author Nguna, Joyce
Okethwangu, Denis
Kabwama, Steven Ndugwa
Aliddeki, Dativa Maria
Kironde, Susan Kizito
Birungi, Doreen
Eurien, Daniel
Ario, Alex Riolexus
Lukoye, Deus
Kasozi, Julius
Cegielski, Peter J.
author_facet Nguna, Joyce
Okethwangu, Denis
Kabwama, Steven Ndugwa
Aliddeki, Dativa Maria
Kironde, Susan Kizito
Birungi, Doreen
Eurien, Daniel
Ario, Alex Riolexus
Lukoye, Deus
Kasozi, Julius
Cegielski, Peter J.
author_sort Nguna, Joyce
collection PubMed
description Communicable diseases, alone or in combination with malnutrition, account for most deaths in complex emergencies including refugee settings. Tuberculosis and HIV/AIDS are increasingly becoming an important cause of morbidity and mortality in refugee settings. We described the treatment outcomes of TB patients and explored factors associated with treatment outcomes among TB patients attending two facilities in Kyangwali Refugee Settlement in Kikuube District, 2016–2017. We abstracted data on laboratory-confirmed patient data from TB registers from 2016 to 2017, in Kikuube Health Centre IV and Rwenyawawa Health Centre II, both located in Kyangwali Refugee Settlement. We abstracted data on socio-demographic variables including age and sex. Other variables were height, weight, final treatment outcomes, demographics, HIV status, TB treatment category, and history of TB. Treatment outcomes were categorized into favorable (including patients who were cured or those who completed treatment) and unfavorable (those in whom treatment failed, those who died, those lost to follow-up, or those not evaluated). We used logistic regression to identify factors associated with unfavorable treatment outcomes. We identified a total of 254 TB patients with a median age of 36 (IQR 26–48) years; 69% (175) were male and 54% (137) were refugees. The median weight was 50.4 kg (range 4–198). Overall, 139 (55%) had favorable outcomes while 115 (45%) had unfavorable outcomes. Refugees formed 53% (71) of those with favorable outcomes and 47% (63) of those with unfavorable outcomes 63(47%). We found that increasing age was statistically associated with unfavorable outcomes, while diagnosis with MDR-TB was associated with decreased odds for unfavorable treatment outcomes. The treatment success rate was lower compared to 85% recommended by WHO. However, the rates are similar to that reported by other studies in Uganda. Innovative approaches to improve treatment success rates with particular focus on persons aged 41–80 years should be devised.
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spelling pubmed-100222562023-03-17 Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017 Nguna, Joyce Okethwangu, Denis Kabwama, Steven Ndugwa Aliddeki, Dativa Maria Kironde, Susan Kizito Birungi, Doreen Eurien, Daniel Ario, Alex Riolexus Lukoye, Deus Kasozi, Julius Cegielski, Peter J. PLOS Glob Public Health Research Article Communicable diseases, alone or in combination with malnutrition, account for most deaths in complex emergencies including refugee settings. Tuberculosis and HIV/AIDS are increasingly becoming an important cause of morbidity and mortality in refugee settings. We described the treatment outcomes of TB patients and explored factors associated with treatment outcomes among TB patients attending two facilities in Kyangwali Refugee Settlement in Kikuube District, 2016–2017. We abstracted data on laboratory-confirmed patient data from TB registers from 2016 to 2017, in Kikuube Health Centre IV and Rwenyawawa Health Centre II, both located in Kyangwali Refugee Settlement. We abstracted data on socio-demographic variables including age and sex. Other variables were height, weight, final treatment outcomes, demographics, HIV status, TB treatment category, and history of TB. Treatment outcomes were categorized into favorable (including patients who were cured or those who completed treatment) and unfavorable (those in whom treatment failed, those who died, those lost to follow-up, or those not evaluated). We used logistic regression to identify factors associated with unfavorable treatment outcomes. We identified a total of 254 TB patients with a median age of 36 (IQR 26–48) years; 69% (175) were male and 54% (137) were refugees. The median weight was 50.4 kg (range 4–198). Overall, 139 (55%) had favorable outcomes while 115 (45%) had unfavorable outcomes. Refugees formed 53% (71) of those with favorable outcomes and 47% (63) of those with unfavorable outcomes 63(47%). We found that increasing age was statistically associated with unfavorable outcomes, while diagnosis with MDR-TB was associated with decreased odds for unfavorable treatment outcomes. The treatment success rate was lower compared to 85% recommended by WHO. However, the rates are similar to that reported by other studies in Uganda. Innovative approaches to improve treatment success rates with particular focus on persons aged 41–80 years should be devised. Public Library of Science 2022-08-02 /pmc/articles/PMC10022256/ /pubmed/36962487 http://dx.doi.org/10.1371/journal.pgph.0000152 Text en © 2022 Nguna et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nguna, Joyce
Okethwangu, Denis
Kabwama, Steven Ndugwa
Aliddeki, Dativa Maria
Kironde, Susan Kizito
Birungi, Doreen
Eurien, Daniel
Ario, Alex Riolexus
Lukoye, Deus
Kasozi, Julius
Cegielski, Peter J.
Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017
title Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017
title_full Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017
title_fullStr Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017
title_full_unstemmed Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017
title_short Factors associated with poor treatment outcomes among tuberculosis patients in Kyangwali Refugee Settlement, Uganda, 2016–2017
title_sort factors associated with poor treatment outcomes among tuberculosis patients in kyangwali refugee settlement, uganda, 2016–2017
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022256/
https://www.ncbi.nlm.nih.gov/pubmed/36962487
http://dx.doi.org/10.1371/journal.pgph.0000152
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