Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis

BACKGROUND: Glioblastoma multiforme (GBM) is characterized by an unfavorable prognosis for patients affected. During standard-of-care chemotherapy using temozolomide (TMZ), tumors acquire resistance thereby causing tumor recurrence. Thus, deciphering essential molecular pathways causing TMZ resistan...

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Detalles Bibliográficos
Autores principales: Stillger, Maren Nicole, Chen, Chia-Yi, Lai, Zon Weng, Li, Mujia, Schäfer, Agnes, Pagenstecher, Axel, Nimsky, Christopher, Bartsch, Jörg Walter, Schilling, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022304/
https://www.ncbi.nlm.nih.gov/pubmed/36932402
http://dx.doi.org/10.1186/s12935-023-02889-8

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