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Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria

Over past decades, there has been increasing geographical spread of Lassa fever (LF) cases across Nigeria and other countries in West Africa. This increase has been associated with significant morbidity and mortality despite increasing focus on the disease by both local and international scientists....

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Autores principales: Olayinka, Adebola T., Elimian, Kelly, Ipadeola, Oladipupo, Dan-Nwafor, Chioma, Gibson, Jack, Ochu, Chinwe, Furuse, Yuki, Iniobong, Akanimo, Akano, Adejoke, Enenche, Lorna, Onoja, Michael, Uzoho, Chukwuemeka, Ugbogulu, Nkem, Makava, Favour, Arinze, Chinedu, Namara, Geoffrey, Muwanguzi, Esther, Jan, Kamji, Ukponu, Winifred, Okwor, Tochi, Anueyiagu, Chimezie, Saleh, Muhammad, Ahumibe, Anthony, Eneh, Chibuzo, Ilori, Elsie, Mba, Nwando, Ihekweazu, Chikwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022364/
https://www.ncbi.nlm.nih.gov/pubmed/36962735
http://dx.doi.org/10.1371/journal.pgph.0000191
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author Olayinka, Adebola T.
Elimian, Kelly
Ipadeola, Oladipupo
Dan-Nwafor, Chioma
Gibson, Jack
Ochu, Chinwe
Furuse, Yuki
Iniobong, Akanimo
Akano, Adejoke
Enenche, Lorna
Onoja, Michael
Uzoho, Chukwuemeka
Ugbogulu, Nkem
Makava, Favour
Arinze, Chinedu
Namara, Geoffrey
Muwanguzi, Esther
Jan, Kamji
Ukponu, Winifred
Okwor, Tochi
Anueyiagu, Chimezie
Saleh, Muhammad
Ahumibe, Anthony
Eneh, Chibuzo
Ilori, Elsie
Mba, Nwando
Ihekweazu, Chikwe
author_facet Olayinka, Adebola T.
Elimian, Kelly
Ipadeola, Oladipupo
Dan-Nwafor, Chioma
Gibson, Jack
Ochu, Chinwe
Furuse, Yuki
Iniobong, Akanimo
Akano, Adejoke
Enenche, Lorna
Onoja, Michael
Uzoho, Chukwuemeka
Ugbogulu, Nkem
Makava, Favour
Arinze, Chinedu
Namara, Geoffrey
Muwanguzi, Esther
Jan, Kamji
Ukponu, Winifred
Okwor, Tochi
Anueyiagu, Chimezie
Saleh, Muhammad
Ahumibe, Anthony
Eneh, Chibuzo
Ilori, Elsie
Mba, Nwando
Ihekweazu, Chikwe
author_sort Olayinka, Adebola T.
collection PubMed
description Over past decades, there has been increasing geographical spread of Lassa fever (LF) cases across Nigeria and other countries in West Africa. This increase has been associated with significant morbidity and mortality despite increasing focus on the disease by both local and international scientists. Many of these studies on LF have been limited to few specialised centres in the country. This study was done to identify sociodemographic and clinical predictors of LF disease and related deaths across Nigeria. We analysed retrospective surveillance data on suspected LF cases collected during January-June 2018 and 2019. Multivariable logistic regression analyses were used to identify the factors independently associated with laboratory–confirmed LF diagnosis, and with LF–related deaths. There were confirmed 815 of 1991 suspected LF cases with complete records during this period. Of these, 724/815 confirmed cases had known clinical outcomes, of whom 100 died. LF confirmation was associated with presentation of gastrointestinal tract (aOR 3.47, 95% CI: 2.79–4.32), ear, nose and throat (aOR 2.73, 95% CI: 1.80–4.15), general systemic (aOR 2.12, 95% CI: 1.65–2.70) and chest/respiratory (aOR 1.71, 95% CI: 1.28–2.29) symptoms. Other factors were being male (aOR 1.32, 95% CI: 1.06–1.63), doing business/trading (aOR 2.16, 95% CI: 1.47–3.16) and farming (aOR 1.73, 95% CI: 1.12–2.68). Factors associated with LF mortality were a one-year increase in age (aOR 1.03, 95% CI: 1.01–1.04), bleeding (aOR 2.07, 95% CI: 1.07–4.00), and central nervous manifestations (aOR 5.02, 95% CI: 3.12–10.16). Diverse factors were associated with both LF disease and related death. A closer look at patterns of clinical variables would be helpful to support early detection and management of cases. The findings would also be useful for planning preparedness and response interventions against LF in the country and region.
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spelling pubmed-100223642023-03-17 Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria Olayinka, Adebola T. Elimian, Kelly Ipadeola, Oladipupo Dan-Nwafor, Chioma Gibson, Jack Ochu, Chinwe Furuse, Yuki Iniobong, Akanimo Akano, Adejoke Enenche, Lorna Onoja, Michael Uzoho, Chukwuemeka Ugbogulu, Nkem Makava, Favour Arinze, Chinedu Namara, Geoffrey Muwanguzi, Esther Jan, Kamji Ukponu, Winifred Okwor, Tochi Anueyiagu, Chimezie Saleh, Muhammad Ahumibe, Anthony Eneh, Chibuzo Ilori, Elsie Mba, Nwando Ihekweazu, Chikwe PLOS Glob Public Health Research Article Over past decades, there has been increasing geographical spread of Lassa fever (LF) cases across Nigeria and other countries in West Africa. This increase has been associated with significant morbidity and mortality despite increasing focus on the disease by both local and international scientists. Many of these studies on LF have been limited to few specialised centres in the country. This study was done to identify sociodemographic and clinical predictors of LF disease and related deaths across Nigeria. We analysed retrospective surveillance data on suspected LF cases collected during January-June 2018 and 2019. Multivariable logistic regression analyses were used to identify the factors independently associated with laboratory–confirmed LF diagnosis, and with LF–related deaths. There were confirmed 815 of 1991 suspected LF cases with complete records during this period. Of these, 724/815 confirmed cases had known clinical outcomes, of whom 100 died. LF confirmation was associated with presentation of gastrointestinal tract (aOR 3.47, 95% CI: 2.79–4.32), ear, nose and throat (aOR 2.73, 95% CI: 1.80–4.15), general systemic (aOR 2.12, 95% CI: 1.65–2.70) and chest/respiratory (aOR 1.71, 95% CI: 1.28–2.29) symptoms. Other factors were being male (aOR 1.32, 95% CI: 1.06–1.63), doing business/trading (aOR 2.16, 95% CI: 1.47–3.16) and farming (aOR 1.73, 95% CI: 1.12–2.68). Factors associated with LF mortality were a one-year increase in age (aOR 1.03, 95% CI: 1.01–1.04), bleeding (aOR 2.07, 95% CI: 1.07–4.00), and central nervous manifestations (aOR 5.02, 95% CI: 3.12–10.16). Diverse factors were associated with both LF disease and related death. A closer look at patterns of clinical variables would be helpful to support early detection and management of cases. The findings would also be useful for planning preparedness and response interventions against LF in the country and region. Public Library of Science 2022-08-26 /pmc/articles/PMC10022364/ /pubmed/36962735 http://dx.doi.org/10.1371/journal.pgph.0000191 Text en © 2022 Olayinka et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Olayinka, Adebola T.
Elimian, Kelly
Ipadeola, Oladipupo
Dan-Nwafor, Chioma
Gibson, Jack
Ochu, Chinwe
Furuse, Yuki
Iniobong, Akanimo
Akano, Adejoke
Enenche, Lorna
Onoja, Michael
Uzoho, Chukwuemeka
Ugbogulu, Nkem
Makava, Favour
Arinze, Chinedu
Namara, Geoffrey
Muwanguzi, Esther
Jan, Kamji
Ukponu, Winifred
Okwor, Tochi
Anueyiagu, Chimezie
Saleh, Muhammad
Ahumibe, Anthony
Eneh, Chibuzo
Ilori, Elsie
Mba, Nwando
Ihekweazu, Chikwe
Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria
title Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria
title_full Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria
title_fullStr Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria
title_full_unstemmed Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria
title_short Analysis of sociodemographic and clinical factors associated with Lassa fever disease and mortality in Nigeria
title_sort analysis of sociodemographic and clinical factors associated with lassa fever disease and mortality in nigeria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022364/
https://www.ncbi.nlm.nih.gov/pubmed/36962735
http://dx.doi.org/10.1371/journal.pgph.0000191
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