Determination of Potentially Novel Compensatory Mutations in rpoC Associated with Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis Clinical Isolates from Peru

BACKGROUND: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among which rpoC may be the most important. We analyzed 469 Pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Vargas, Ana Paula, Rios, Angela A., Grandjean, Louis, Kirwan, Daniela E., Gilman, Robert H., Sheen, Patricia, Zimic, Mirko J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022416/
https://www.ncbi.nlm.nih.gov/pubmed/32474533
http://dx.doi.org/10.4103/ijmy.ijmy_27_20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022416/
https://www.ncbi.nlm.nih.gov/pubmed/32474533
http://dx.doi.org/10.4103/ijmy.ijmy_27_20

Ejemplares similares