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Determination of Potentially Novel Compensatory Mutations in rpoC Associated with Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis Clinical Isolates from Peru
BACKGROUND: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among which rpoC may be the most important. We analyzed 469 Pe...
Autores principales: | Vargas, Ana Paula, Rios, Angela A., Grandjean, Louis, Kirwan, Daniela E., Gilman, Robert H., Sheen, Patricia, Zimic, Mirko J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022416/ https://www.ncbi.nlm.nih.gov/pubmed/32474533 http://dx.doi.org/10.4103/ijmy.ijmy_27_20 |
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