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Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones

Micro-computed tomography (micro-CT) and cone-beam computed tomography (CBCT), in conjunction with the image fusion technique, may provide similar results for trauma assessment after cochlear implantation, with respect to the trauma evaluation in preclinical cochlear implant (CI) studies, as the his...

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Autores principales: Iso-Mustajärvi, Matti, Silvast, Tuomo, Heikka, Tuomas, Tervaniemi, Jyrki, Calixto, Roger, Linder, Pia H., Dietz, Aarno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022666/
https://www.ncbi.nlm.nih.gov/pubmed/36843083
http://dx.doi.org/10.1097/MAO.0000000000003835
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author Iso-Mustajärvi, Matti
Silvast, Tuomo
Heikka, Tuomas
Tervaniemi, Jyrki
Calixto, Roger
Linder, Pia H.
Dietz, Aarno
author_facet Iso-Mustajärvi, Matti
Silvast, Tuomo
Heikka, Tuomas
Tervaniemi, Jyrki
Calixto, Roger
Linder, Pia H.
Dietz, Aarno
author_sort Iso-Mustajärvi, Matti
collection PubMed
description Micro-computed tomography (micro-CT) and cone-beam computed tomography (CBCT), in conjunction with the image fusion technique, may provide similar results for trauma assessment after cochlear implantation, with respect to the trauma evaluation in preclinical cochlear implant (CI) studies, as the histology. BACKGROUND: Before clinical use, novel cochlear implant (CI) designs are tested in temporal bone (TB) studies for usability and risk evaluation. The criterion standard for evaluating intracochlear insertion trauma and electrode location has historically been with histological samples. Progress of modern imaging technology has created alternatives to classic histology. This study compares the micro-CT and CBCT fusion images between histological samples in a preclinical CI study. METHODS: Fourteen freshly frozen TBs were inserted with a lateral wall research CI electrode. All TBs were scanned with CBCT preoperatively and postoperatively. After insertion, the TBs were prepared for micro-CT and histology. Twelve TBs underwent first a micro-CT and then the histological process. The CBCTs were used for image fusion, and all three different methods were used for intracochlear trauma evaluation. The results were compared between methods. RESULTS: There were 4 of 14 translocations detected with the fusion image method and 3 of 12 with the micro-CT and histology. When compared, the trauma grades converged and were not statistically significant. CONCLUSION: The trauma grading based on micro-CT is comparable to the histology. The image fusion technique based on CBCT is less accurate because it relies on an empirical assumption of the basal membrane localization, but it is clinically applicable.
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spelling pubmed-100226662023-03-18 Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones Iso-Mustajärvi, Matti Silvast, Tuomo Heikka, Tuomas Tervaniemi, Jyrki Calixto, Roger Linder, Pia H. Dietz, Aarno Otol Neurotol Cochlear Implants Micro-computed tomography (micro-CT) and cone-beam computed tomography (CBCT), in conjunction with the image fusion technique, may provide similar results for trauma assessment after cochlear implantation, with respect to the trauma evaluation in preclinical cochlear implant (CI) studies, as the histology. BACKGROUND: Before clinical use, novel cochlear implant (CI) designs are tested in temporal bone (TB) studies for usability and risk evaluation. The criterion standard for evaluating intracochlear insertion trauma and electrode location has historically been with histological samples. Progress of modern imaging technology has created alternatives to classic histology. This study compares the micro-CT and CBCT fusion images between histological samples in a preclinical CI study. METHODS: Fourteen freshly frozen TBs were inserted with a lateral wall research CI electrode. All TBs were scanned with CBCT preoperatively and postoperatively. After insertion, the TBs were prepared for micro-CT and histology. Twelve TBs underwent first a micro-CT and then the histological process. The CBCTs were used for image fusion, and all three different methods were used for intracochlear trauma evaluation. The results were compared between methods. RESULTS: There were 4 of 14 translocations detected with the fusion image method and 3 of 12 with the micro-CT and histology. When compared, the trauma grades converged and were not statistically significant. CONCLUSION: The trauma grading based on micro-CT is comparable to the histology. The image fusion technique based on CBCT is less accurate because it relies on an empirical assumption of the basal membrane localization, but it is clinically applicable. Lippincott Williams & Wilkins 2023-04 2023-02-22 /pmc/articles/PMC10022666/ /pubmed/36843083 http://dx.doi.org/10.1097/MAO.0000000000003835 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Otology & Neurotology, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cochlear Implants
Iso-Mustajärvi, Matti
Silvast, Tuomo
Heikka, Tuomas
Tervaniemi, Jyrki
Calixto, Roger
Linder, Pia H.
Dietz, Aarno
Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
title Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
title_full Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
title_fullStr Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
title_full_unstemmed Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
title_short Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
title_sort trauma after cochlear implantation: the accuracy of micro–computed tomography and cone-beam fusion computed tomography compared with histology in human temporal bones
topic Cochlear Implants
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022666/
https://www.ncbi.nlm.nih.gov/pubmed/36843083
http://dx.doi.org/10.1097/MAO.0000000000003835
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