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Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones
Micro-computed tomography (micro-CT) and cone-beam computed tomography (CBCT), in conjunction with the image fusion technique, may provide similar results for trauma assessment after cochlear implantation, with respect to the trauma evaluation in preclinical cochlear implant (CI) studies, as the his...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022666/ https://www.ncbi.nlm.nih.gov/pubmed/36843083 http://dx.doi.org/10.1097/MAO.0000000000003835 |
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author | Iso-Mustajärvi, Matti Silvast, Tuomo Heikka, Tuomas Tervaniemi, Jyrki Calixto, Roger Linder, Pia H. Dietz, Aarno |
author_facet | Iso-Mustajärvi, Matti Silvast, Tuomo Heikka, Tuomas Tervaniemi, Jyrki Calixto, Roger Linder, Pia H. Dietz, Aarno |
author_sort | Iso-Mustajärvi, Matti |
collection | PubMed |
description | Micro-computed tomography (micro-CT) and cone-beam computed tomography (CBCT), in conjunction with the image fusion technique, may provide similar results for trauma assessment after cochlear implantation, with respect to the trauma evaluation in preclinical cochlear implant (CI) studies, as the histology. BACKGROUND: Before clinical use, novel cochlear implant (CI) designs are tested in temporal bone (TB) studies for usability and risk evaluation. The criterion standard for evaluating intracochlear insertion trauma and electrode location has historically been with histological samples. Progress of modern imaging technology has created alternatives to classic histology. This study compares the micro-CT and CBCT fusion images between histological samples in a preclinical CI study. METHODS: Fourteen freshly frozen TBs were inserted with a lateral wall research CI electrode. All TBs were scanned with CBCT preoperatively and postoperatively. After insertion, the TBs were prepared for micro-CT and histology. Twelve TBs underwent first a micro-CT and then the histological process. The CBCTs were used for image fusion, and all three different methods were used for intracochlear trauma evaluation. The results were compared between methods. RESULTS: There were 4 of 14 translocations detected with the fusion image method and 3 of 12 with the micro-CT and histology. When compared, the trauma grades converged and were not statistically significant. CONCLUSION: The trauma grading based on micro-CT is comparable to the histology. The image fusion technique based on CBCT is less accurate because it relies on an empirical assumption of the basal membrane localization, but it is clinically applicable. |
format | Online Article Text |
id | pubmed-10022666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100226662023-03-18 Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones Iso-Mustajärvi, Matti Silvast, Tuomo Heikka, Tuomas Tervaniemi, Jyrki Calixto, Roger Linder, Pia H. Dietz, Aarno Otol Neurotol Cochlear Implants Micro-computed tomography (micro-CT) and cone-beam computed tomography (CBCT), in conjunction with the image fusion technique, may provide similar results for trauma assessment after cochlear implantation, with respect to the trauma evaluation in preclinical cochlear implant (CI) studies, as the histology. BACKGROUND: Before clinical use, novel cochlear implant (CI) designs are tested in temporal bone (TB) studies for usability and risk evaluation. The criterion standard for evaluating intracochlear insertion trauma and electrode location has historically been with histological samples. Progress of modern imaging technology has created alternatives to classic histology. This study compares the micro-CT and CBCT fusion images between histological samples in a preclinical CI study. METHODS: Fourteen freshly frozen TBs were inserted with a lateral wall research CI electrode. All TBs were scanned with CBCT preoperatively and postoperatively. After insertion, the TBs were prepared for micro-CT and histology. Twelve TBs underwent first a micro-CT and then the histological process. The CBCTs were used for image fusion, and all three different methods were used for intracochlear trauma evaluation. The results were compared between methods. RESULTS: There were 4 of 14 translocations detected with the fusion image method and 3 of 12 with the micro-CT and histology. When compared, the trauma grades converged and were not statistically significant. CONCLUSION: The trauma grading based on micro-CT is comparable to the histology. The image fusion technique based on CBCT is less accurate because it relies on an empirical assumption of the basal membrane localization, but it is clinically applicable. Lippincott Williams & Wilkins 2023-04 2023-02-22 /pmc/articles/PMC10022666/ /pubmed/36843083 http://dx.doi.org/10.1097/MAO.0000000000003835 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Otology & Neurotology, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cochlear Implants Iso-Mustajärvi, Matti Silvast, Tuomo Heikka, Tuomas Tervaniemi, Jyrki Calixto, Roger Linder, Pia H. Dietz, Aarno Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones |
title | Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones |
title_full | Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones |
title_fullStr | Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones |
title_full_unstemmed | Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones |
title_short | Trauma After Cochlear Implantation: The Accuracy of Micro–Computed Tomography and Cone-Beam Fusion Computed Tomography Compared With Histology in Human Temporal Bones |
title_sort | trauma after cochlear implantation: the accuracy of micro–computed tomography and cone-beam fusion computed tomography compared with histology in human temporal bones |
topic | Cochlear Implants |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022666/ https://www.ncbi.nlm.nih.gov/pubmed/36843083 http://dx.doi.org/10.1097/MAO.0000000000003835 |
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