Cargando…
Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria
BACKGROUND: Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover of collagen type III is associated with development of kidney fibrosis. We investigated whether a degradation product of collagen type III (C3M) was a risk marker for progression of chronic kidney...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022760/ https://www.ncbi.nlm.nih.gov/pubmed/36930632 http://dx.doi.org/10.1371/journal.pone.0283296 |
_version_ | 1784908786896470016 |
---|---|
author | Poulsen, Christina Gjerlev Rasmussen, Daniel G. K. Genovese, Federica Hansen, Tine W. Nielsen, Signe Holm Reinhard, Henrik von Scholten, Bernt Johan Jacobsen, Peter K. Parving, Hans-Henrik Karsdal, Morten Asser Rossing, Peter Frimodt-Møller, Marie |
author_facet | Poulsen, Christina Gjerlev Rasmussen, Daniel G. K. Genovese, Federica Hansen, Tine W. Nielsen, Signe Holm Reinhard, Henrik von Scholten, Bernt Johan Jacobsen, Peter K. Parving, Hans-Henrik Karsdal, Morten Asser Rossing, Peter Frimodt-Møller, Marie |
author_sort | Poulsen, Christina Gjerlev |
collection | PubMed |
description | BACKGROUND: Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover of collagen type III is associated with development of kidney fibrosis. We investigated whether a degradation product of collagen type III (C3M) was a risk marker for progression of chronic kidney disease (CKD), occurrence of cardiovascular disease (CVD), and mortality during follow up in people with type 2 diabetes (T2D) and microalbuminuria. Moreover, we investigated whether C3M was correlated with markers of inflammation and endothelial dysfunction at baseline. METHODS: C3M was measured in serum (sC3M) and urine (uC3M) in 200 participants with T2D and microalbuminuria included in an observational, prospective study at Steno Diabetes Center Copenhagen in Denmark from 2007–2008. Baseline measurements included 12 markers of inflammation and endothelial dysfunction. The endpoints were CVD, mortality, and CKD progression (>30% decline in eGFR). RESULTS: Mean (SD) age was 59 (9) years, eGFR 90 (17) ml/min/1.73m(2) and median (IQR) urine albumin excretion rate 102 (39–229) mg/24-h. At baseline all markers for inflammation were positively correlated with sC3M (p≤0.034). Some, but not all, markers for endothelial dysfunction were correlated with C3M. Median follow-up ranged from 4.9 to 6.3 years. Higher sC3M was associated with CKD progression (with mortality as competing risk) with a hazard ratio (per doubling) of 2.98 (95% CI: 1.41–6.26; p = 0.004) adjusted for traditional risk factors. uC3M was not associated with CKD progression. Neither sC3M or uC3M were associated with risk of CVD or mortality. CONCLUSIONS: Higher sC3M was a risk factor for chronic kidney disease progression and was correlated with markers of inflammation. |
format | Online Article Text |
id | pubmed-10022760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-100227602023-03-18 Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria Poulsen, Christina Gjerlev Rasmussen, Daniel G. K. Genovese, Federica Hansen, Tine W. Nielsen, Signe Holm Reinhard, Henrik von Scholten, Bernt Johan Jacobsen, Peter K. Parving, Hans-Henrik Karsdal, Morten Asser Rossing, Peter Frimodt-Møller, Marie PLoS One Research Article BACKGROUND: Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover of collagen type III is associated with development of kidney fibrosis. We investigated whether a degradation product of collagen type III (C3M) was a risk marker for progression of chronic kidney disease (CKD), occurrence of cardiovascular disease (CVD), and mortality during follow up in people with type 2 diabetes (T2D) and microalbuminuria. Moreover, we investigated whether C3M was correlated with markers of inflammation and endothelial dysfunction at baseline. METHODS: C3M was measured in serum (sC3M) and urine (uC3M) in 200 participants with T2D and microalbuminuria included in an observational, prospective study at Steno Diabetes Center Copenhagen in Denmark from 2007–2008. Baseline measurements included 12 markers of inflammation and endothelial dysfunction. The endpoints were CVD, mortality, and CKD progression (>30% decline in eGFR). RESULTS: Mean (SD) age was 59 (9) years, eGFR 90 (17) ml/min/1.73m(2) and median (IQR) urine albumin excretion rate 102 (39–229) mg/24-h. At baseline all markers for inflammation were positively correlated with sC3M (p≤0.034). Some, but not all, markers for endothelial dysfunction were correlated with C3M. Median follow-up ranged from 4.9 to 6.3 years. Higher sC3M was associated with CKD progression (with mortality as competing risk) with a hazard ratio (per doubling) of 2.98 (95% CI: 1.41–6.26; p = 0.004) adjusted for traditional risk factors. uC3M was not associated with CKD progression. Neither sC3M or uC3M were associated with risk of CVD or mortality. CONCLUSIONS: Higher sC3M was a risk factor for chronic kidney disease progression and was correlated with markers of inflammation. Public Library of Science 2023-03-17 /pmc/articles/PMC10022760/ /pubmed/36930632 http://dx.doi.org/10.1371/journal.pone.0283296 Text en © 2023 Poulsen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Poulsen, Christina Gjerlev Rasmussen, Daniel G. K. Genovese, Federica Hansen, Tine W. Nielsen, Signe Holm Reinhard, Henrik von Scholten, Bernt Johan Jacobsen, Peter K. Parving, Hans-Henrik Karsdal, Morten Asser Rossing, Peter Frimodt-Møller, Marie Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
title | Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
title_full | Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
title_fullStr | Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
title_full_unstemmed | Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
title_short | Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
title_sort | marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022760/ https://www.ncbi.nlm.nih.gov/pubmed/36930632 http://dx.doi.org/10.1371/journal.pone.0283296 |
work_keys_str_mv | AT poulsenchristinagjerlev markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT rasmussendanielgk markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT genovesefederica markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT hansentinew markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT nielsensigneholm markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT reinhardhenrik markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT vonscholtenberntjohan markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT jacobsenpeterk markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT parvinghanshenrik markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT karsdalmortenasser markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT rossingpeter markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria AT frimodtmøllermarie markerforkidneyfibrosisisassociatedwithinflammationanddeteriorationofkidneyfunctioninpeoplewithtype2diabetesandmicroalbuminuria |