Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor immune evasion in mouse models of breast cancer. Deletion of Kindlin-1 in...

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Detalles Bibliográficos
Autores principales: Webb, Emily R, Dodd, Georgia L, Noskova, Michaela, Bullock, Esme, Muir, Morwenna, Frame, Margaret C, Serrels, Alan, Brunton, Valerie G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023156/
https://www.ncbi.nlm.nih.gov/pubmed/36883731
http://dx.doi.org/10.7554/eLife.85739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023156/
https://www.ncbi.nlm.nih.gov/pubmed/36883731
http://dx.doi.org/10.7554/eLife.85739

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