Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

Phase separation plays crucial roles in both sustaining cellular function and perpetuating disease states. Despite extensive studies, our understanding of this process is hindered by low solubility of phase-separating proteins. One example of this is found in SR and SR-related proteins. These protei...

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Detalles Bibliográficos
Autores principales: Fargason, Talia, De Silva, Naiduwadura Ivon Upekala, King, Erin, Zhang, Zihan, Paul, Trenton, Shariq, Jamal, Zaharias, Steve, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023157/
https://www.ncbi.nlm.nih.gov/pubmed/36862748
http://dx.doi.org/10.7554/eLife.84412

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