Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT

BACKGROUND: Radiotherapy impacts the local immune response to cancers. Prostate Stereotactic Body Radiotherapy (SBRT) is a highly focused method to deliver radiotherapy often used to treat prostate cancer. This is the first direct comparison of immune cells within prostate cancers before and after S...

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Autores principales: Kane, Nathanael, Romero, Tahmineh, Diaz-Perez, Silvia, Rettig, Matthew B., Steinberg, Michael L., Kishan, Amar U., Schaue, Dorthe, Reiter, Robert E., Knudsen, Beatrice S., Nickols, Nicholas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023555/
https://www.ncbi.nlm.nih.gov/pubmed/35058580
http://dx.doi.org/10.1038/s41391-022-00498-6
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author Kane, Nathanael
Romero, Tahmineh
Diaz-Perez, Silvia
Rettig, Matthew B.
Steinberg, Michael L.
Kishan, Amar U.
Schaue, Dorthe
Reiter, Robert E.
Knudsen, Beatrice S.
Nickols, Nicholas G.
author_facet Kane, Nathanael
Romero, Tahmineh
Diaz-Perez, Silvia
Rettig, Matthew B.
Steinberg, Michael L.
Kishan, Amar U.
Schaue, Dorthe
Reiter, Robert E.
Knudsen, Beatrice S.
Nickols, Nicholas G.
author_sort Kane, Nathanael
collection PubMed
description BACKGROUND: Radiotherapy impacts the local immune response to cancers. Prostate Stereotactic Body Radiotherapy (SBRT) is a highly focused method to deliver radiotherapy often used to treat prostate cancer. This is the first direct comparison of immune cells within prostate cancers before and after SBRT in patients. METHODS: Prostate cancers before and 2 weeks after SBRT are interrogated by multiplex immune fluorescence targeting various T cells and macrophages markers and analyzed by cell and pixel density, as part of a clinical trial of SBRT neoadjuvant to radical prostatectomy. RESULTS: Two weeks after SBRT, CD68, and CD163 macrophages are significantly increased while CD8 T cells are decreased. SBRT markedly alters the immune environment within prostate cancers.
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spelling pubmed-100235552023-03-19 Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT Kane, Nathanael Romero, Tahmineh Diaz-Perez, Silvia Rettig, Matthew B. Steinberg, Michael L. Kishan, Amar U. Schaue, Dorthe Reiter, Robert E. Knudsen, Beatrice S. Nickols, Nicholas G. Prostate Cancer Prostatic Dis Brief Communication BACKGROUND: Radiotherapy impacts the local immune response to cancers. Prostate Stereotactic Body Radiotherapy (SBRT) is a highly focused method to deliver radiotherapy often used to treat prostate cancer. This is the first direct comparison of immune cells within prostate cancers before and after SBRT in patients. METHODS: Prostate cancers before and 2 weeks after SBRT are interrogated by multiplex immune fluorescence targeting various T cells and macrophages markers and analyzed by cell and pixel density, as part of a clinical trial of SBRT neoadjuvant to radical prostatectomy. RESULTS: Two weeks after SBRT, CD68, and CD163 macrophages are significantly increased while CD8 T cells are decreased. SBRT markedly alters the immune environment within prostate cancers. Nature Publishing Group UK 2022-01-20 2023 /pmc/articles/PMC10023555/ /pubmed/35058580 http://dx.doi.org/10.1038/s41391-022-00498-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Kane, Nathanael
Romero, Tahmineh
Diaz-Perez, Silvia
Rettig, Matthew B.
Steinberg, Michael L.
Kishan, Amar U.
Schaue, Dorthe
Reiter, Robert E.
Knudsen, Beatrice S.
Nickols, Nicholas G.
Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
title Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
title_full Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
title_fullStr Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
title_full_unstemmed Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
title_short Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT
title_sort significant changes in macrophage and cd8 t cell densities in primary prostate tumors 2 weeks after sbrt
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023555/
https://www.ncbi.nlm.nih.gov/pubmed/35058580
http://dx.doi.org/10.1038/s41391-022-00498-6
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