The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production

The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer’s disease (AD) etiology. Canonical cleavages by β- and γ-secretases lead to Aβ production which accumulate in amyloid plaques. Recently, the matrix metalloprotease MT5-MMP, referred to as η-secre...

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Detalles Bibliográficos
Autores principales: Afram, Elissa, Lauritzen, Inger, Bourgeois, Alexandre, El Manaa, Wejdane, Duplan, Eric, Chami, Mounia, Valverde, Audrey, Charlotte, Bauer, Pardossi-Piquard, Raphaëlle, Checler, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023608/
https://www.ncbi.nlm.nih.gov/pubmed/36930302
http://dx.doi.org/10.1007/s00018-023-04737-4

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