The immune microenviroment in somatotropinomas: from biology to personalized and target therapy

Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biol...

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Autores principales: Chiloiro, Sabrina, De Marinis, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023617/
https://www.ncbi.nlm.nih.gov/pubmed/36658300
http://dx.doi.org/10.1007/s11154-022-09782-1
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author Chiloiro, Sabrina
De Marinis, Laura
author_facet Chiloiro, Sabrina
De Marinis, Laura
author_sort Chiloiro, Sabrina
collection PubMed
description Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors. In this paper, we will review data of TME and target therapies in somatotropinomas.
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spelling pubmed-100236172023-03-19 The immune microenviroment in somatotropinomas: from biology to personalized and target therapy Chiloiro, Sabrina De Marinis, Laura Rev Endocr Metab Disord Article Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors. In this paper, we will review data of TME and target therapies in somatotropinomas. Springer US 2023-01-20 2023 /pmc/articles/PMC10023617/ /pubmed/36658300 http://dx.doi.org/10.1007/s11154-022-09782-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chiloiro, Sabrina
De Marinis, Laura
The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
title The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
title_full The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
title_fullStr The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
title_full_unstemmed The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
title_short The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
title_sort immune microenviroment in somatotropinomas: from biology to personalized and target therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023617/
https://www.ncbi.nlm.nih.gov/pubmed/36658300
http://dx.doi.org/10.1007/s11154-022-09782-1
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