Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression

Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the regulation of tumorigenesis, the role in intestinal tumor development remains to be elucid...

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Detalles Bibliográficos
Autores principales: Tang, Ce, Sun, Haiyang, Kadoki, Motohiko, Han, Wei, Ye, Xiaoqi, Makusheva, Yulia, Deng, Jianping, Feng, Bingbing, Qiu, Ding, Tan, Ying, Wang, Xinying, Guo, Zehao, Huang, Chanyan, Peng, Sui, Chen, Minhu, Adachi, Yoshiyuki, Ohno, Naohito, Trombetta, Sergio, Iwakura, Yoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023663/
https://www.ncbi.nlm.nih.gov/pubmed/36932082
http://dx.doi.org/10.1038/s41467-023-37229-x

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