Cargando…
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides
Naturally occurring peptides with high membrane permeability often have ester bonds on their backbones. However, the impact of amide-to-ester substitutions on the membrane permeability of peptides has not been directly evaluated. Here we report the effect of amide-to-ester substitutions on the membr...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023679/ https://www.ncbi.nlm.nih.gov/pubmed/36932083 http://dx.doi.org/10.1038/s41467-023-36978-z |