Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides

Naturally occurring peptides with high membrane permeability often have ester bonds on their backbones. However, the impact of amide-to-ester substitutions on the membrane permeability of peptides has not been directly evaluated. Here we report the effect of amide-to-ester substitutions on the membr...

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Detalles Bibliográficos
Autores principales: Hosono, Yuki, Uchida, Satoshi, Shinkai, Moe, Townsend, Chad E., Kelly, Colin N., Naylor, Matthew R., Lee, Hsiau-Wei, Kanamitsu, Kayoko, Ishii, Mayumi, Ueki, Ryosuke, Ueda, Takumi, Takeuchi, Koh, Sugita, Masatake, Akiyama, Yutaka, Lokey, Scott R., Morimoto, Jumpei, Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023679/
https://www.ncbi.nlm.nih.gov/pubmed/36932083
http://dx.doi.org/10.1038/s41467-023-36978-z

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