Cargando…

The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex–mediated quiescence

The hematopoietic stem cell (HSC) cycle responds to inflammatory and other proliferative stressors; however, these cells must quickly return to quiescence to avoid exhaustion and maintain their functional integrity. The mechanisms that regulate this return to quiescence are not well understood. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Greenberg, Zev J., Paracatu, Luana Chiquetto, Monlish, Darlene A., Dong, Qian, Rettig, Michael, Roundy, Nate, Gaballa, Rofaida, Li, Weikai, Yang, Wei, Luke, Cliff J., Schuettpelz, Laura G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Hematopoiesis and Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023726/ https://www.ncbi.nlm.nih.gov/pubmed/36542833 http://dx.doi.org/10.1182/blood.2022016929

Ejemplares similares

Toll-like receptor and cytokine expression throughout the bone marrow differs between patients with low- and high-risk myelodysplastic syndromes
por: Paracatu, Luana Chiquetto, et al.
Publicado: (2022)

Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells
por: Warsi, Sarah, et al.
Publicado: (2022)

The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes
por: Higgins, Cassandra B., et al.
Publicado: (2022)

Machine learning–based scoring models to predict hematopoietic stem cell mobilization in allogeneic donors
por: Xiang, Jingyu, et al.
Publicado: (2022)

Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes
por: Paracatu, Luana Chiquetto, et al.
Publicado: (2020)

Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity
por: Zhang, Tong, et al.
Publicado: (2023)

Physioxia improves the selectivity of hematopoietic stem cell expansion cultures
por: Igarashi, Kyomi J., et al.
Publicado: (2023)

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development
por: Bresciani, Erica, et al.
Publicado: (2021)

Pembrolizumab for the treatment of disease relapse after allogeneic hematopoietic stem cell transplantation
por: Godfrey, James, et al.
Publicado: (2022)

A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation
por: Rowan, Courtney M., et al.
Publicado: (2022)

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal
por: Aljoufi, Arafat, et al.
Publicado: (2022)

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal
por: Keyvani Chahi, Ava, et al.
Publicado: (2022)

A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation
por: Wang, Chen, et al.
Publicado: (2023)

An NFIX-mediated regulatory network governs the balance of hematopoietic stem and progenitor cells during hematopoiesis
por: Walker, Megan, et al.
Publicado: (2022)

Deleterious effect of bone marrow-resident macrophages on hematopoietic stem cells in response to total body irradiation
por: Chalot, Marion, et al.
Publicado: (2022)

Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation
por: Zhang, Nanyan, et al.
Publicado: (2022)

Cell-free DNA measurable residual disease as a predictor of postallogeneic hematopoietic cell transplant outcomes
por: Pasca, Sergiu, et al.
Publicado: (2023)

Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification
por: Cao, Huimin, et al.
Publicado: (2023)

Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation
por: Zeng, Xiangjun, et al.
Publicado: (2023)

Assessment of safety and immunogenicity of MHC homozygous iPSC-derived CD34(+) hematopoietic progenitors in an NHP model
por: D’Souza, Saritha S., et al.
Publicado: (2022)

Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition
por: Koyunlar, Cansu, et al.
Publicado: (2023)

Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches
por: Yu, Zhuo, et al.
Publicado: (2022)

LNK (SH2B3) inhibition expands healthy and Fanconi anemia human hematopoietic stem and progenitor cells
por: Holdreith, Nicholas, et al.
Publicado: (2022)

Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injury
por: Chen, Naicheng, et al.
Publicado: (2023)

A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation
por: Wang, Fengjiao, et al.
Publicado: (2021)

R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling
por: Chan, Kathy Yuen Yee, et al.
Publicado: (2021)

p16INK4A-dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors
por: Hellmich, Charlotte, et al.
Publicado: (2022)

The Role of Toll-Like Receptors in Hematopoietic Malignancies
por: Monlish, Darlene A., et al.
Publicado: (2016)

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes
por: Walne, Amanda J., et al.
Publicado: (2008)

spib is required for primitive myeloid development in Xenopus
por: Costa, Ricardo M. B., et al.
Publicado: (2008)

A HaemAtlas: characterizing gene expression in differentiated human blood cells
por: Watkins, Nicholas A., et al.
Publicado: (2009)

STAT1 is essential for HSC function and maintains MHCII(hi) stem cells that resist myeloablation and neoplastic expansion
por: Li, Juan, et al.
Publicado: (2022)

Epigenetic plasticity of erythroid progenitors
por: Brand, Marjorie
Publicado: (2021)

Novel population of human monocyte and osteoclast progenitors from pluripotent stem cells and peripheral blood
por: Root, Sierra H., et al.
Publicado: (2021)

KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia
por: Arede, Liliana, et al.
Publicado: (2022)

Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress
por: Landspersky, Theresa, et al.
Publicado: (2022)

Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue
por: Sharma, Richa, et al.
Publicado: (2022)

Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT
por: Mizuno, Kana, et al.
Publicado: (2022)

M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands
por: Hason, Martina, et al.
Publicado: (2022)

GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program
por: Johnson, Kirby D., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3upge91uscl70jrcm7r46n8658