RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia

Gain of chromosome 21 (Hsa21) is among the most frequent aneuploidies in leukemia. However, it remains unclear how partial or complete amplifications of Hsa21 promote leukemogenesis and why children with Down syndrome (DS) (ie, trisomy 21) are particularly at risk of leukemia development. Here, we p...

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Detalles Bibliográficos
Autores principales: Gialesaki, Sofia, Bräuer-Hartmann, Daniela, Issa, Hasan, Bhayadia, Raj, Alejo-Valle, Oriol, Verboon, Lonneke, Schmell, Anna-Lena, Laszig, Stephanie, Regényi, Enikő, Schuschel, Konstantin, Labuhn, Maurice, Ng, Michelle, Winkler, Robert, Ihling, Christian, Sinz, Andrea, Glaß, Markus, Hüttelmaier, Stefan, Matzk, Sören, Schmid, Lena, Strüwe, Farina Josepha, Kadel, Sofie-Katrin, Reinhardt, Dirk, Yaspo, Marie-Laure, Heckl, Dirk, Klusmann, Jan-Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Plenary Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023736/
https://www.ncbi.nlm.nih.gov/pubmed/36493345
http://dx.doi.org/10.1182/blood.2022017619

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