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Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years

Idiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently in patients aged > 50 years. Pulmonary vessel-like volume...

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Autores principales: John, Joyce, Clark, Alys R., Kumar, Haribalan, Vandal, Alain C., Burrowes, Kelly S., Wilsher, Margaret L., Milne, David G., Bartholmai, Brian, Levin, David L., Karwoski, Ronald, Tawhai, Merryn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023743/
https://www.ncbi.nlm.nih.gov/pubmed/36932117
http://dx.doi.org/10.1038/s41598-023-31470-6
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author John, Joyce
Clark, Alys R.
Kumar, Haribalan
Vandal, Alain C.
Burrowes, Kelly S.
Wilsher, Margaret L.
Milne, David G.
Bartholmai, Brian
Levin, David L.
Karwoski, Ronald
Tawhai, Merryn H.
author_facet John, Joyce
Clark, Alys R.
Kumar, Haribalan
Vandal, Alain C.
Burrowes, Kelly S.
Wilsher, Margaret L.
Milne, David G.
Bartholmai, Brian
Levin, David L.
Karwoski, Ronald
Tawhai, Merryn H.
author_sort John, Joyce
collection PubMed
description Idiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently in patients aged > 50 years. Pulmonary vessel-like volume (PVV) has been found to be an independent predictor of mortality in IPF and other interstitial lung diseases, however its estimation can be impacted by artefacts associated with image segmentation methods and can be confounded by adjacent fibrosis. This study compares PVV in IPF patients (N = 21) with PVV from a healthy cohort aged > 50 years (N = 59). The analysis includes a connected graph-based approach that aims to minimise artefacts contributing to calculation of PVV. We show that despite a relatively low extent of fibrosis in the IPF cohort (20% of the lung volume), PVV is 2–3 times higher than in controls. This suggests that a standardised method to calculate PVV that accounts for tree connectivity could provide a promising tool to provide early diagnostic or prognostic information in IPF patients and other interstitial lung disease.
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spelling pubmed-100237432023-03-19 Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years John, Joyce Clark, Alys R. Kumar, Haribalan Vandal, Alain C. Burrowes, Kelly S. Wilsher, Margaret L. Milne, David G. Bartholmai, Brian Levin, David L. Karwoski, Ronald Tawhai, Merryn H. Sci Rep Article Idiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently in patients aged > 50 years. Pulmonary vessel-like volume (PVV) has been found to be an independent predictor of mortality in IPF and other interstitial lung diseases, however its estimation can be impacted by artefacts associated with image segmentation methods and can be confounded by adjacent fibrosis. This study compares PVV in IPF patients (N = 21) with PVV from a healthy cohort aged > 50 years (N = 59). The analysis includes a connected graph-based approach that aims to minimise artefacts contributing to calculation of PVV. We show that despite a relatively low extent of fibrosis in the IPF cohort (20% of the lung volume), PVV is 2–3 times higher than in controls. This suggests that a standardised method to calculate PVV that accounts for tree connectivity could provide a promising tool to provide early diagnostic or prognostic information in IPF patients and other interstitial lung disease. Nature Publishing Group UK 2023-03-17 /pmc/articles/PMC10023743/ /pubmed/36932117 http://dx.doi.org/10.1038/s41598-023-31470-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
John, Joyce
Clark, Alys R.
Kumar, Haribalan
Vandal, Alain C.
Burrowes, Kelly S.
Wilsher, Margaret L.
Milne, David G.
Bartholmai, Brian
Levin, David L.
Karwoski, Ronald
Tawhai, Merryn H.
Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
title Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
title_full Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
title_fullStr Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
title_full_unstemmed Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
title_short Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
title_sort pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023743/
https://www.ncbi.nlm.nih.gov/pubmed/36932117
http://dx.doi.org/10.1038/s41598-023-31470-6
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