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Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication

This study aims to explore the prevalence of creatinine kinase elevation amongst a sample of Dutch adolescents admitted for acute alcohol intoxication. The data on all admitted adolescents < 18 years old with acute alcohol intoxication between 2008 and 2021 were collected from a Dutch major distr...

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Autores principales: Pigeaud, Louise, de Veld, Loes, van der Lely, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023758/
https://www.ncbi.nlm.nih.gov/pubmed/36662269
http://dx.doi.org/10.1007/s00431-023-04820-9
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author Pigeaud, Louise
de Veld, Loes
van der Lely, Nico
author_facet Pigeaud, Louise
de Veld, Loes
van der Lely, Nico
author_sort Pigeaud, Louise
collection PubMed
description This study aims to explore the prevalence of creatinine kinase elevation amongst a sample of Dutch adolescents admitted for acute alcohol intoxication. The data on all admitted adolescents < 18 years old with acute alcohol intoxication between 2008 and 2021 were collected from a Dutch major district general hospital, Reinier de Graaf Gasthuis, in Delft. Overall, 495 adolescents who were treated for symptoms of acute alcohol intoxication during this period were included in the study. When evaluating the blood samples of the included patients, elevated creatinine kinase levels were found in 60% of the cases, with a mean of 254 U/I (normal value ≤ 145 U/I). A confirmed diagnosis of rhabdomyolysis (increase in CK > fivefold the upper limit of normal) was present in 4.4% of cases. Moreover, using a linear regression this study found that a higher blood alcohol concentration was associated with higher creatinine kinase levels, when adjusted for positive drug screenings amongst the adolescents with acute alcohol intoxication (p = 0.027; β = 66.88; 95% CI 7.68 − 126.08).     Conclusions: This is the first study focusing on how acute alcohol intoxication affects adolescents’ muscle tissue. The results could potentially help to prevent alcohol use within the sports world. It could also aid understanding of how acute alcohol intoxication influences the breakdown of adolescents’ muscle tissue.
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spelling pubmed-100237582023-03-19 Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication Pigeaud, Louise de Veld, Loes van der Lely, Nico Eur J Pediatr Research This study aims to explore the prevalence of creatinine kinase elevation amongst a sample of Dutch adolescents admitted for acute alcohol intoxication. The data on all admitted adolescents < 18 years old with acute alcohol intoxication between 2008 and 2021 were collected from a Dutch major district general hospital, Reinier de Graaf Gasthuis, in Delft. Overall, 495 adolescents who were treated for symptoms of acute alcohol intoxication during this period were included in the study. When evaluating the blood samples of the included patients, elevated creatinine kinase levels were found in 60% of the cases, with a mean of 254 U/I (normal value ≤ 145 U/I). A confirmed diagnosis of rhabdomyolysis (increase in CK > fivefold the upper limit of normal) was present in 4.4% of cases. Moreover, using a linear regression this study found that a higher blood alcohol concentration was associated with higher creatinine kinase levels, when adjusted for positive drug screenings amongst the adolescents with acute alcohol intoxication (p = 0.027; β = 66.88; 95% CI 7.68 − 126.08).     Conclusions: This is the first study focusing on how acute alcohol intoxication affects adolescents’ muscle tissue. The results could potentially help to prevent alcohol use within the sports world. It could also aid understanding of how acute alcohol intoxication influences the breakdown of adolescents’ muscle tissue. Springer Berlin Heidelberg 2023-01-20 2023 /pmc/articles/PMC10023758/ /pubmed/36662269 http://dx.doi.org/10.1007/s00431-023-04820-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Pigeaud, Louise
de Veld, Loes
van der Lely, Nico
Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication
title Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication
title_full Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication
title_fullStr Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication
title_full_unstemmed Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication
title_short Elevated creatinine kinase levels amongst Dutch adolescents with acute alcohol intoxication
title_sort elevated creatinine kinase levels amongst dutch adolescents with acute alcohol intoxication
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023758/
https://www.ncbi.nlm.nih.gov/pubmed/36662269
http://dx.doi.org/10.1007/s00431-023-04820-9
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