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Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers

A comprehensive evaluation of the total burden of morbidity endured by cancer survivors remains unavailable. This study quantified the burden of 144 health conditions and critical care admissions across 26 adult cancers and treatment modalities in 243,767 adults. By age 60, top conditions ranked by...

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Autores principales: Chang, Wai Hoong, Neal, Richard D., Forster, Martin D., Lai, Alvina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023774/
https://www.ncbi.nlm.nih.gov/pubmed/36932095
http://dx.doi.org/10.1038/s41467-023-37231-3
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author Chang, Wai Hoong
Neal, Richard D.
Forster, Martin D.
Lai, Alvina G.
author_facet Chang, Wai Hoong
Neal, Richard D.
Forster, Martin D.
Lai, Alvina G.
author_sort Chang, Wai Hoong
collection PubMed
description A comprehensive evaluation of the total burden of morbidity endured by cancer survivors remains unavailable. This study quantified the burden of 144 health conditions and critical care admissions across 26 adult cancers and treatment modalities in 243,767 adults. By age 60, top conditions ranked by fold difference (cumulative burden in survivors divided by cumulative burden in controls) were haematology, immunology/infection and pulmonary conditions. Patients who had all three forms of treatment (chemotherapy, radiotherapy and surgery) experienced a high cumulative burden of late morbidities compared with patients who received radiotherapy alone. The top five cancers with the highest cumulative burden of critical care admissions by age 60 were bone (12.4 events per 100 individuals [CI: 11.6-13.1]), brain (9.0 [7.5-10.5]), spinal cord and nervous system (7.2 [6.7-7.8]), testis (6.7 [4.9-8.4]) and Hodgkin lymphoma (4.4 [3.6-5.1]). Conditions that were associated with high excess years-of-life-lost were haematological conditions (9.6 years), pulmonary conditions (8.6 years) and immunological conditions or infections (7.8 years). As the population of cancer survivors continues to grow, our results indicate that it is important to tackle long-term health consequences through enacting data-driven policies.
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spelling pubmed-100237742023-03-19 Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers Chang, Wai Hoong Neal, Richard D. Forster, Martin D. Lai, Alvina G. Nat Commun Article A comprehensive evaluation of the total burden of morbidity endured by cancer survivors remains unavailable. This study quantified the burden of 144 health conditions and critical care admissions across 26 adult cancers and treatment modalities in 243,767 adults. By age 60, top conditions ranked by fold difference (cumulative burden in survivors divided by cumulative burden in controls) were haematology, immunology/infection and pulmonary conditions. Patients who had all three forms of treatment (chemotherapy, radiotherapy and surgery) experienced a high cumulative burden of late morbidities compared with patients who received radiotherapy alone. The top five cancers with the highest cumulative burden of critical care admissions by age 60 were bone (12.4 events per 100 individuals [CI: 11.6-13.1]), brain (9.0 [7.5-10.5]), spinal cord and nervous system (7.2 [6.7-7.8]), testis (6.7 [4.9-8.4]) and Hodgkin lymphoma (4.4 [3.6-5.1]). Conditions that were associated with high excess years-of-life-lost were haematological conditions (9.6 years), pulmonary conditions (8.6 years) and immunological conditions or infections (7.8 years). As the population of cancer survivors continues to grow, our results indicate that it is important to tackle long-term health consequences through enacting data-driven policies. Nature Publishing Group UK 2023-03-17 /pmc/articles/PMC10023774/ /pubmed/36932095 http://dx.doi.org/10.1038/s41467-023-37231-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chang, Wai Hoong
Neal, Richard D.
Forster, Martin D.
Lai, Alvina G.
Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
title Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
title_full Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
title_fullStr Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
title_full_unstemmed Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
title_short Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
title_sort cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023774/
https://www.ncbi.nlm.nih.gov/pubmed/36932095
http://dx.doi.org/10.1038/s41467-023-37231-3
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