Trio-pharmacophore DNA-encoded chemical library for simultaneous selection of fragments and linkers

The split-and-pool method has been widely used to synthesize chemical libraries of a large size for early drug discovery, albeit without the possibility of meaningful quality control. In contrast, a self-assembled DNA-encoded chemical library (DEL) allows us to construct an m x n-member library by m...

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Detalles Bibliográficos
Autores principales: Cui, Meiying, Nguyen, Dzung, Gaillez, Michelle Patino, Heiden, Stephan, Lin, Weilin, Thompson, Michael, Reddavide, Francesco V., Chen, Qinchang, Zhang, Yixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023787/
https://www.ncbi.nlm.nih.gov/pubmed/36932079
http://dx.doi.org/10.1038/s41467-023-37071-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023787/
https://www.ncbi.nlm.nih.gov/pubmed/36932079
http://dx.doi.org/10.1038/s41467-023-37071-1

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