Cargando…
Trio-pharmacophore DNA-encoded chemical library for simultaneous selection of fragments and linkers
The split-and-pool method has been widely used to synthesize chemical libraries of a large size for early drug discovery, albeit without the possibility of meaningful quality control. In contrast, a self-assembled DNA-encoded chemical library (DEL) allows us to construct an m x n-member library by m...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023787/ https://www.ncbi.nlm.nih.gov/pubmed/36932079 http://dx.doi.org/10.1038/s41467-023-37071-1 |